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Enzymatic assay of human HDAC6 with custom peptide substrate
Assay data:5601 Tested
SummaryRelated BioAssays by Target
Enzymatic assay of human HDAC6 with commercial peptide substrate
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
Assay data:7175 Tested
Summary
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20 M by FRET kind of response from peptide substrate
Assay data:7174 Tested
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging
Assay data:5611 Tested
Apparent permeability across apical to basolateral side in human Caco2 cells after 2 hrs by HPLC analysis
Assay data:4 Tested
SummaryPubMed Citation
Apparent permeability across basolateral to apical side in human Caco2 cells after 2 hrs by HPLC analysis
Drug metabolism in human Caco2 cells assessed as compound glucuronidation/sulfation at 100 uM after 48 hrs by HPLC analysis
Assay data:1 Tested
Drug metabolism assessed as Helix pomatia beta-glucuronidase/sulfatase type H-5-mediated secoisolariciresinol formation in 48 hrs compound-treated human Caco2 cell lysate prior to enzyme addition measured up to 48 hrs by HPLC analysis
Stability in HBSS after 48 hrs
Antioxidant activity assessed as reduction of K3FeCN6 at 1 to 500 uM by spectrophotometric analysis in presence of FeCl3
Assay data:4 Active, 4 Tested
SummaryCompounds, ActivePubMed Citation
Antioxidant activity assessed as reduction of K3FeCN6 by spectrophotometric analysis in presence of FeCl3
Antioxidant activity assessed as gallic acid equivalents of hydroxyl radical scavenging activity by fluorescence assay
Assay data:2 Tested
Antioxidant activity assessed as hydroxyl radical scavenging activity at 8 uM to 1 mM by fluorescence assay relative to gallic acid
Antioxidant activity assessed as trolox equivalents of peroxyl radical scavenging activity by fluorescence assay
Antioxidant activity assessed as peroxyl radical scavenging activity at 8 uM to 1 mM by fluorescence assay relative to trolox
Antioxidant activity assessed as DPPH radical scavenging activity at 5 to 500 uM incubated for 20 mins under dark condition by spectrophotometric analysis
Antioxidant activity assessed as DPPH radical scavenging activity incubated for 20 mins under dark condition by spectrophotometric analysis
Ratio of ascorbic acid acid EC50 to compound EC50 for reduction of K3FeCN6
Ratio of alpha-tocopherol EC50 to compound EC50 for reduction of K3FeCN6
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