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Selectivity index, ratio of Ki for inhibition of HexB (unknown origin) to Ki for inhibition of OGA (unknown origin)
Assay data:1 Tested
SummaryPubMed Citation
Inhibition of OGA (unknown origin) using pNP-O-GlcNAc as substrate assessed as inhibition constant incubated for 30 mins
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of lysosomal hexosaminidase (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of rat spleen OGA
Inhibition of OGA in mouse NIH/3T3 cells assessed as increase in O-GlcNAcylation at 20 uM after 24 hrs by Western blot analysis
Assay data:3 Active, 3 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of Ostrinia furnacalis Hex1 expressed in Pichia pastoris at 100 uM using 4-MU-GlcNAc as substrate measured after 30 mins by fluorescence assay relative to control
Assay data:16 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of recombinant human OGA expressed in Escherichia coli BL21(DE3) at 100 uM using 4-MU-GlcNAc as substrate measured after 30 mins by fluorescence assay relative to control
Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB
Assay data:3916 Active, 206 Activity ≤ 1 nM, 1830 Activity ≤ 1 µM, 3916 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB
Assay data:3598 Active, 421 Activity ≤ 1 nM, 2233 Activity ≤ 1 µM, 3598 Tested
Ratio of human 84 O-GLcNAcase to Vibrio cholerae NagZ
Assay data:10 Tested
Inhibition of human family 20 beta-hexosaminidase
Assay data:2 Active, 1 Activity ≤ 1 µM, 9 Tested
Inhibition of human family 84 O-GLcNAcase
Assay data:5 Active, 2 Activity ≤ 1 µM, 10 Tested
Inhibition of Vibrio cholerae NagZ
Assay data:8 Active, 6 Activity ≤ 1 µM, 10 Tested
Experimentally measured binding affinity data derived from PDB
Assay data:3073 Active, 3073 Tested
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