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Cytotoxicity activity against human HepG2 cells assessed by CellTiter-Glo luminescent cell viability assay.
Assay data:1241 Active, 184 Activity ≤ 1 µM, 1545 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µM
Antiproliferative activity against human BXPC-3 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Induction of apoptosis in human HepG2 cells assessed as total apoptotic cells at 5 uM incubated for 24 hrs by Annexin-V/PI staining based flow cytometry (Rvb=5.14%)
Assay data:2 Tested
SummaryPubMed Citation
Induction of apoptosis in human HepG2 cells assessed as increase in cleaved caspase-3 level at 2.5 uM incubated for 24 hrs by Western blot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Induction of apoptosis in human HepG2 cells assessed as increase in p21 level at 2.5 uM incubated for 24 hrs by Western blot analysis
Induction of apoptosis in human HepG2 cells assessed as viable cells at 5 uM incubated for 24 hrs by Annexin-V/PI staining based flow cytometry (Rvb=94.0%)
Induction of apoptosis in human HepG2 cells assessed as late apoptotic cells at 5 uM incubated for 24 hrs by Annexin-V/PI staining based flow cytometry (Rvb=0.66%)
Induction of apoptosis in human HepG2 cells assessed as early apoptotic cells at 5 uM incubated for 24 hrs by Annexin-V/PI staining based flow cytometry (Rvb=4.48%)
Induction of apoptosis in human HepG2 cells assessed as necrotic cells at 5 uM incubated for 24 hrs by Annexin-V/PI staining based flow cytometry (Rvb=0.85%)
Induction of cell cycle arrest in human HepG2 cells assessed as accumulation at G2/M phase at 5 uM incubated for 24 hrs by flow cytometry (Rvb= 14.05%)
Induction of cell cycle arrest in human HepG2 cells assessed as accumulation at S phase at 5 uM incubated for 24 hrs by flow cytometry (Rvb= 20.1%)
Induction of cell cycle arrest in human HepG2 cells assessed as accumulation at G0/G1 phase at 5 uM incubated for 24 hrs by flow cytometry (Rvb= 46.5%)
Inhibition of c-myc expression in human HepG2 cells at 5 uM incubated for 24 hrs by Western blot analysis
Cytotoxicity against human GES1 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Assay data:10 Active, 11 Activity ≤ 1 µM, 11 Tested
Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Assay data:8 Active, 11 Activity ≤ 1 µM, 11 Tested
Inhibition of BRD4 BD1 (unknown origin) by TR-FRET assay
Assay data:21 Active, 1 Activity ≤ 1 nM, 10 Activity ≤ 1 µM, 21 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of BRD4 (unknown origin)
Assay data:6 Active, 5 Activity ≤ 1 µM, 6 Tested
Inhibition of Alexa647 labelled MS417 binding to his tagged BRD4 BD2 (unknown origin) by TR-FRET assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
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