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Inhibition of human BACE1 in HEK293 cells transfected with wild type APP assessed as reduction of amyloid beta40 level after 18 to 20 hrs by AlphaLISA technique
Assay data:36 Active, 4 Activity ≤ 1 nM, 36 Activity ≤ 1 µM, 36 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Selectivity ratio of IC50 for human BACE1 to IC50 for BACE1 in HEK293 cells
Assay data:36 Tested
SummaryPubMed CitationRelated BioAssays by Target
Selectivity ratio of IC50 for human BACE2 to IC50 for human BACE1
Assay data:22 Tested
SummaryPubMed Citation
Inhibition of human BACE2 using MR121-labeled substrate incubated for 4 mins prior to substrate addition measured after 2 mins by spectrophotometric analysis
Assay data:25 Active, 23 Activity ≤ 1 µM, 25 Tested
Inhibition of human BACE1 using MR121-labeled substrate incubated for 4 mins prior to substrate addition measured after 2 mins by spectrophotometric analysis
Assay data:36 Active, 36 Activity ≤ 1 µM, 37 Tested
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