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Antiplasmodial activity against Plasmodium vivax assessed as parasitic growth inhibition
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Summary
Antiplasmodial activity against Plasmodium falciparum FCR-3 assessed as plasmodial growth inhibition
Half life in human plasma at 500 mg, po by LC-MS/MS analysis
Assay data:1 Tested
Antiplasmodial activity against immature stage gametocytes Plasmodium falciparum NF54 incubated for 48 hrs by luciferase activity assay
Assay data:5 Active, 1 Activity ≤ 1 µM, 5 Tested
NCATS Human Liver Microsomal (HLM) Stability Profiling
Assay data:542 Active, 900 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Depositor
Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: luciferase cell-based qHTS assay
Assay data:2481 Active, 355 Activity ≤ 1 µM, 5246 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Depositor
p53 small molecule agonists, cell-based qHTS assay with human liver microsomes: Summary
Assay data:70 Active, 12 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
p53 small molecule agonists, cell-based qHTS assay: Summary
Assay data:212 Active, 41 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same Project
p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary
Assay data:103 Active, 14 Activity ≤ 1 µM, 9667 Tested
p53 small molecule agonists, cell-based qHTS assay
Assay data:87 Active, 5 Activity ≤ 1 nM, 180 Activity ≤ 1 µM, 9667 Tested
p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter screen
Assay data:213 Active, 2 Activity ≤ 1 nM, 241 Activity ≤ 1 µM, 9667 Tested
p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS cell viability counter screen
Assay data:214 Active, 153 Activity ≤ 1 µM, 9667 Tested
p53 small molecule agonists, cell-based qHTS assay with human liver microsomes: qHTS cell viability counter screen
Assay data:300 Active, 138 Activity ≤ 1 µM, 9667 Tested
p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes
Assay data:27 Active, 44 Activity ≤ 1 µM, 9667 Tested
p53 small molecule agonists, cell-based qHTS assay with human liver microsomes
Assay data:43 Active, 55 Activity ≤ 1 µM, 9667 Tested
Cytotoxicity activity against human HepG2 cells assessed by CellTiter-Glo luminescent cell viability assay.
Assay data:1241 Active, 184 Activity ≤ 1 µM, 1545 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µM
Antiplasmodial activity against Plasmodium falciparum gametocytes by [3H]hypoxanthine incorporation assay
Assay data:3 Tested
SummaryPubMed Citation
Antiplasmodial activity against early stage (I to III) Plasmodium falciparum incubated for 48 hrs by bioluminescence assay
Assay data:4 Active, 1 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Anticancer activity against human HepG2 cells
Assay data:3 Active, 1 Activity ≤ 1 µM, 3 Tested
Binding affinity to calf thymus DNA sequence
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
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