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Agonist activity at human P2Y14 expressed in rat CHO cells
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at human P2Y14 expressed in rat C6 cells
Agonist activity at human P2Y14 expressed in HEK293 cells
Antagonist activity at rat P2Y14
Antagonist activity at P2Y14 (unknown origin) assessed as binding constant
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Antagonist activity at P2Y6 (unknown origin)
Inhibition of Mycobacterium tuberculosis UGM expressed in Escherichia coli BL21(DE3) assessed as formation of UDP-galactopyranose at 500 uM preincubated for 5 min followed by substrate addition and measured after 1 to 3 mins using UDP-galactofuranose as substrate by HPLC analysis relative to control
Assay data:5 Tested
Inhibition of Mycobacterium tuberculosis UGM expressed in Escherichia coli BL21(DE3) assessed as dissociation constant by fluorescence polarization assay
Assay data:8 Tested
Inhibition of Klebsiella pneumoniae UGM expressed in Escherichia coli BL21(DE3) assessed as dissociation constant by fluorescence polarization assay
SummaryPubMed Citation
Inhibition of Mycobacterium tuberculosis UGM expressed in Escherichia coli BL21(DE3) at 500 uM by Fluorescence polarization assay relative to control
Assay data:11 Tested
Inhibition of Klebsiella pneumoniae UGM expressed in Escherichia coli BL21(DE3) at 500 uM by Fluorescence polarization assay relative to control
Primary qHTS assay for inhibitors of human arachidonate 12S-lipoxygenase (ALOX12): Round 2
Assay data:6069 Active, 5332 Activity ≤ 1 µM, 575118 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Validation qHTS for agonist of cAMP-regulated guanine nucleotide exchange factor 4 (EPAC2)
Assay data:41 Active, 124 Activity ≤ 1 µM, 15613 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Validation qHTS for antagonist of cAMP-regulated guanine nucleotide exchange factor 4 (EPAC2)
Assay data:265 Active, 171 Activity ≤ 1 µM, 15637 Tested
Validation qHTS for agonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1)
Assay data:160 Active, 22 Activity ≤ 1 µM, 15634 Tested
Validation qHTS for antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1)
Assay data:115 Active, 91 Activity ≤ 1 µM, 15634 Tested
Competitive inhibition of recombinant His-tagged yeast GYS2P expressed in Escherichia coli BL21(DE3) cells using UDPG as substrate in presence of G-6-P by 14C-glucose incorporation based Michaelis-Menton plot analysis
Assay data:2 Tested
Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay
Assay data:41 Active, 8 Activity ≤ 1 nM, 357 Activity ≤ 1 µM, 11292 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Depositor
Drug metabolism at 2 mM at pH 1.7 at room temperature after 28 days by 31P NMR method
Cell-based high-throughput assay to identify small molecules that inhibit phospholipid biosynthesis in animal cells 4: screen of the LOPAC library.
Assay data:12 Active, 1265 Tested
SummaryCompounds, ActiveRelated BioAssays by Depositor
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