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Inhibition of gamma-secretase expressed in african green monkey CV1 cells co-expressing Gal4 DNA-binding/transactivation domain assessed as inhibition of notch processing after 22 hrs by luciferase reporter assay
Assay data:7 Active, 10 Tested
SummaryCompounds, ActivePubMed Citation
Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant Swedish variant of APP K595N/M596L assessed as reduction of amyloid beta40 level after 48 hrs by AlphaLISA assay
Assay data:15 Active, 5 Activity ≤ 1 µM, 20 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of gamma-secretase in human SHSY5Y cells expressing human recombinant Swedish variant of APP K595N/M596L assessed as reduction of amyloid beta42 level after 48 hrs by AlphaLISA assay
Assay data:17 Active, 15 Activity ≤ 1 µM, 20 Tested
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