Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Selectivity ratio of IC50 for TrkC (unknown origin) to IC50 for PK-tagged human Trkalpha
Assay data:1 Tested
SummaryPubMed Citation
Plasma protein binding in rat
Assay data:3 Tested
Half life in rat at 2 mg/kg
Cmax in rat at 10 mg/kg, po
Assay data:3 Active, 1 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of TrkC (unknown origin)
SummaryPubMed CitationRelated BioAssays by Target
Clearance in rat at 2 mg/kg
Oral bioavailability in rat at 10 mg/kg
Inhibition of PK-tagged human Trkalpha expressed in human U2OS cells assessed as reduction in beta NGF-induced EA-tagged SHC1 recruitment pretreated for 1 hr followed by beta NGF stimulation measured after 3 hrs by PathHunter assay
Assay data:23 Active, 10 Activity ≤ 1 µM, 43 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
HIV1_TAR : FRET assay measuring displacement of FAM and TAMRA-labeled Tat peptide from HIV-1 TAR RNA.
Assay data:618 Active, 103146 Tested
SummaryCompounds, Active
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on