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Ratio of AUC (0 to infinity) in brain to plasma of C57BL mouse at 20 mg/kg, iv by HPLC/MS/MS method
Assay data:1 Tested
SummaryPubMed Citation
Antagonist activity at resistant Smo D473H mutant (unknown origin) expressed in mouse C3H 10T1/2 cells cotransfected with Gli reporter gene assessed as Gli luciferase activity incubated for 24 hrs by dual luciferase assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Equilibrium solubility of the compound at pH 6.8
Assay data:1 Active, 9 Tested
SummaryCompounds, Active
Displacement of radio-labeled smoothened agonist from human Smo by radio-ligand competition binding assay
Assay data:142 Active, 142 Activity ≤ 1 µM, 142 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Displacement of radio-labeled smoothened agonist from mouse Smo by radio-ligand competition binding assay
Assay data:140 Active, 140 Activity ≤ 1 µM, 140 Tested
Inhibition of mouse recombinant Shh protein in mouse TMHh12 cells assessed as inhibition of 25 nM Smo agonist-induced hedgehog signalling response by Gli-luciferase reporter gene assay
Assay data:144 Active, 144 Activity ≤ 1 µM, 144 Tested
Inhibition of mouse recombinant Shh protein in mouse TMHh12 cells assessed as inhibition of 1 nM Smo agonist-induced hedgehog signalling response by Gli-luciferase reporter gene assay
Inhibition of Smo D473H mutant (unknown origin) expressed in mouse C3H10T1/2 cells by luciferase assay
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