BioAssays for PubChem Compound (Select 25206346) - PubChem BioAssay - NCBI

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Select item 9776081.

Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB

Source:: Shanghai Institute of Organic Chemistry

Protein Targets:: Chain 1, Chymotrypsinogen A; ...
Total:: 3277

Assay data:4302 Active, 250 Activity ≤ 1 nM, 2931 Activity ≤ 1 µM, 4302 Tested

AID:: 977608

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Depositor Related BioAssays by Target

Select item 7153472.

Inhibition of recombinant BRAF V600E mutant using GSTP1-MEK1 and [gamma-32P]ATP as substrate after 30 mins by scintillation counting

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase B-raf

Assay data:8 Active, 8 Activity ≤ 1 µM, 8 Tested

AID:: 715347

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 7153463.

Inhibition of VEGFR2

Source:: ChEMBL

Protein Target:: Vascular endothelial growth factor receptor 2

Assay data:8 Active, 8 Activity ≤ 1 µM, 8 Tested

AID:: 715346

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 7153454.

Inhibition of BRAF V600E mutant in human HT-29 cells assessed as reduction of MRK phosphorylation

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase B-raf

Assay data:7 Active, 8 Activity ≤ 1 µM, 8 Tested

AID:: 715345

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 7153445.

Intrinsic clearance in human liver microsomes at 1 umol/L after 20 mins in presence of NADPH

Source:: ChEMBL

Assay data:8 Tested

AID:: 715344

Summary PubMed Citation

Select item 7153436.

Intrinsic clearance in mouse liver microsomes at 1 umol/L after 20 mins in presence of NADPH

Source:: ChEMBL

Assay data:4 Tested

AID:: 715343

Summary PubMed Citation

Select item 7153427.

Inhibition of VEGFR2 in HUVEC assessed as reduction of VGF-stimulated cell proliferation after 5 days

Source:: ChEMBL

Protein Target:: Vascular endothelial growth factor receptor 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 715342

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 7153418.

Inhibition of wild type human BRAF (445 to 726) expressed in Sf9 insect cells

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase B-raf

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 715341

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 7153409.

Inhibition of c-RAF

Source:: ChEMBL

Protein Target:: RAF proto-oncogene serine/threonine-protein kinase

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 715340

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 71533910.

Inhibition of FGFR3

Source:: ChEMBL

Protein Target:: Fibroblast growth factor receptor 3

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 715339

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 71533811.

Inhibition of PDGFRbeta

Source:: ChEMBL

Protein Target:: Platelet-derived growth factor receptor beta

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 715338

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 71533712.

Inhibition of PDGFRalpha

Source:: ChEMBL

Protein Target:: Platelet-derived growth factor receptor alpha

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 715337

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 71533613.

Inhibition of EGFR

Source:: ChEMBL

Protein Target:: Epidermal growth factor receptor

Assay data:1 Tested

AID:: 715336

Summary PubMed Citation Related BioAssays by Target

Select item 71533514.

Inhibition of HER2

Source:: ChEMBL

Protein Target:: Receptor tyrosine-protein kinase erbB-2

Assay data:1 Active, 1 Tested

AID:: 715335

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 71533415.

Inhibition of c-Met

Source:: ChEMBL

Protein Target:: Hepatocyte growth factor receptor

Assay data:1 Tested

AID:: 715334

Summary PubMed Citation Related BioAssays by Target

Select item 71533316.

Inhibition of TIE2

Source:: ChEMBL

Protein Target:: Angiopoietin-1 receptor

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 715333

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 71533217.

Inhibition of c-Kit

Source:: ChEMBL

Protein Target:: Mast/stem cell growth factor receptor Kit

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 715332

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 71533118.

Inhibition of Src

Source:: ChEMBL

Protein Target:: Proto-oncogene tyrosine-protein kinase Src

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 715331

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 71533019.

Inhibition of IR

Source:: ChEMBL

Protein Target:: Insulin receptor

Assay data:1 Tested

AID:: 715330

Summary PubMed Citation Related BioAssays by Target

Select item 71532920.

Inhibition of IKKbeta

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit beta

Assay data:1 Active, 1 Tested

AID:: 715329

Summary Compounds, Active PubMed Citation Related BioAssays by Target

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Proteins (1)
BioAssays with protein sequences specified as targets

BioActivity

Active Compounds (19)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (1)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (15)
BioAssays with the active concentration of tested reagents less than 1 micromolar

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Confirmatory (30)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

Depositor Category

Literature Extraction (34)
BioAssays extracted from the literature

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