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Assay of Substrate Hydrolysis from Article 10.1021/bi401043w: "The natural product dihydrotanshinone I provides a prototype for uncharged inhibitors that bind specifically to the acetylcholinesterase peripheral site with nanomolar affinity."
Assay data:13 Active, 2 Activity ≤ 1 nM, 12 Activity ≤ 1 µM, 14 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Carcinogenesis bioassays from the Carcinogenic Potency Database (CPDB)
Assay data:1547 Tested
Summary
DrugMatrix - Regimen: Single
Assay data:132 Tested
DrugMatrix - Regimen: Daily Repeat
Assay data:654 Tested
Open TG-GATES - Regimen: Single
Assay data:158 Tested
CCRIS carcinogenicity studies
Assay data:1139 Active, 1767 Tested
SummaryCompounds, Active
GENE-TOX mutagenicity studies
Assay data:1995 Active, 3214 Tested
CCRIS mutagenicity studies
Assay data:4929 Active, 8266 Tested
Mutagenicity in Salmonella typhimurium strain TA92 assessed as number of bacterial revertants after 2 days by Ames test in presence of rat liver S9 fraction
Assay data:20 Tested
SummaryPubMed Citation
Growth inhibition of human MCF10A cells after 72 hrs by celltiter-blue viability assay
Assay data:1 Active, 4 Tested
SummaryCompounds, ActivePubMed Citation
Growth inhibition of human MCF7 cells after 72 hrs by celltiter-blue viability assay
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
TP_TRANSPORTER: Northern blot in vivo Fischer male rat
Assay data:5 Tested
SummaryPubMed CitationRelated BioAssays by Target
Drug Induced Liver Injury Prediction System (DILIps) validation dataset; compound DILI positive/negative as observed in Pfizer data
Assay data:148 Tested
DRUGMATRIX: Leukotriene, BLT (LTB4) radioligand binding (ligand: [3H]LTB4)
Assay data:5 Active, 2 Activity ≤ 1 µM, 871 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µM
DRUGMATRIX: Interleukin IL-1 radioligand binding (ligand: [125I] interleukin 1beta)
Assay data:871 Tested
DRUGMATRIX: Insulin radioligand binding (ligand: [125I] Insulin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 871 Tested
SummaryRelated BioAssays by Target
DRUGMATRIX: Imidazoline I2, Central radioligand binding (ligand: [3H] Idazoxan)
Assay data:60 Active, 30 Activity ≤ 1 µM, 871 Tested
DRUGMATRIX: HMG-CoA Reductase enzyme inhibition (substrate: [14C]HMG-CoA)
Assay data:9 Active, 3 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 871 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
DRUGMATRIX: Histamine H2 radioligand binding (ligand: [125I] Aminopotentidine)
Assay data:39 Active, 9 Activity ≤ 1 µM, 871 Tested
DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)
Assay data:49 Active, 12 Activity ≤ 1 nM, 45 Activity ≤ 1 µM, 871 Tested
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