BioAssays for PubChem Compound (Select 171358519) - PubChem BioAssay - NCBI

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Select item 19477031.

Cytotoxicity against mouse HT-22 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay

Source:: ChEMBL

Assay data:17 Active, 4 Activity ≤ 1 µM, 56 Tested

AID:: 1947703

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 19477012.

Binding affinity to human GSK-3beta assessed as residence time measured upto 240 min by TR-FRET assay

Source:: ChEMBL

Protein Target:: Glycogen synthase kinase-3 beta

Assay data:37 Tested

AID:: 1947701

Summary PubMed Citation Related BioAssays by Target

Select item 19477003.

Binding affinity to human CLK1 assessed as residence time measured upto 240 min by TR-FRET assay

Source:: ChEMBL

Protein Target:: Dual specificity protein kinase CLK1

Assay data:37 Tested

AID:: 1947700

Summary PubMed Citation Related BioAssays by Target

Select item 19476994.

Binding affinity to human DYRK1A assessed as residence time measured upto 240 min by TR-FRET assay

Source:: ChEMBL

Protein Target:: Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Assay data:37 Tested

AID:: 1947699

Summary PubMed Citation Related BioAssays by Target

Select item 19476985.

Binding affinity to human GSK-3beta assessed as equilibrium dissociation constant measured upto 240 min by TR-FRET assay

Source:: ChEMBL

Protein Target:: Glycogen synthase kinase-3 beta

Assay data:25 Active, 1 Activity ≤ 1 nM, 15 Activity ≤ 1 µM, 37 Tested

AID:: 1947698

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19476976.

Binding affinity to human CLK1 assessed as equilibrium dissociation constant measured upto 240 min by TR-FRET assay

Source:: ChEMBL

Protein Target:: Dual specificity protein kinase CLK1

Assay data:36 Active, 11 Activity ≤ 1 nM, 37 Activity ≤ 1 µM, 37 Tested

AID:: 1947697

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19476967.

Binding affinity to human DYRK1A assessed as equilibrium dissociation constant measured upto 240 min by TR-FRET assay

Source:: ChEMBL

Protein Target:: Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Assay data:33 Active, 12 Activity ≤ 1 nM, 37 Activity ≤ 1 µM, 37 Tested

AID:: 1947696

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19476958.

Selectivity ratio of IC50 for recombinant human DYRK1B expressed in Sf9 insect cells to IC50 for recombinant human DYRK1A expressed in Escherichia coli

Source:: ChEMBL

Assay data:35 Tested

AID:: 1947695

Summary PubMed Citation

Select item 19476949.

Selectivity ratio of IC50 for recombinant human CLK1 expressed in Sf9 insect cells to IC50 for recombinant human DYRK1A expressed in Escherichia coli

Source:: ChEMBL

Assay data:34 Tested

AID:: 1947694

Summary PubMed Citation

Select item 194769310.

Inhibition of recombinant human DYRK1B expressed in Sf9 insect cells using DYRKtide peptide as substrate incubated for 110 mins in presence of ATP by non-radioactive ADP-Glo luminescence microplate reader assay

Source:: ChEMBL

Protein Target:: Dual specificity tyrosine-phosphorylation-regulated kinase 1B

Assay data:34 Active, 31 Activity ≤ 1 µM, 35 Tested

AID:: 1947693

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 194769211.

Inhibition of recombinant human DYRK1A expressed in Escherichia coli using DYRKtide peptide as substrate incubated for 110 mins in presence of ATP by non-radioactive ADP-Glo luminescence microplate reader assay

Source:: ChEMBL

Protein Target:: Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Assay data:35 Active, 32 Activity ≤ 1 µM, 35 Tested

AID:: 1947692

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 194769112.

Inhibition of recombinant human CLK1 expressed in Sf9 insect cells using myelin basic protein as substrate incubated for 110 mins in presence of ATP by non-radioactive ADP-Glo luminescence microplate reader assay

Source:: ChEMBL

Protein Target:: Dual specificity protein kinase CLK1

Assay data:32 Active, 29 Activity ≤ 1 µM, 35 Tested

AID:: 1947691

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 194769013.

Selectivity ratio of IC50 for recombinant human GSK-3beta expressed in Sf9 insect cells to IC50 for recombinant human DYRK1A expressed in Sf9 insect cells

Source:: ChEMBL

Assay data:48 Tested

AID:: 1947690

Summary PubMed Citation

Select item 194768914.

Selectivity ratio of IC50 for recombinant human DYRK1B expressed in Sf9 insect cells to IC50 for recombinant human DYRK1A expressed in Sf9 insect cells

Source:: ChEMBL

Assay data:48 Tested

AID:: 1947689

Summary PubMed Citation

Select item 194768815.

Selectivity ratio of IC50 for recombinant human CLK1 expressed in Sf9 insect cells to IC50 for recombinant human DYRK1A expressed in Sf9 insect cells

Source:: ChEMBL

Assay data:46 Tested

AID:: 1947688

Summary PubMed Citation

Select item 194768716.

Inhibition of recombinant human GSK-3beta expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scintillation counter analysis

Source:: ChEMBL

Protein Target:: Glycogen synthase kinase-3 beta

Assay data:24 Active, 8 Activity ≤ 1 µM, 56 Tested

AID:: 1947687

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 194768617.

Inhibition of recombinant human DYRK4 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scintillation counter analysis

Source:: ChEMBL

Protein Target:: Dual specificity tyrosine-phosphorylation-regulated kinase 4

Assay data:24 Active, 11 Activity ≤ 1 µM, 56 Tested

AID:: 1947686

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 194768518.

Inhibition of recombinant human DYRK3 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scintillation counter analysis

Source:: ChEMBL

Protein Target:: Dual specificity tyrosine-phosphorylation-regulated kinase 3

Assay data:28 Active, 13 Activity ≤ 1 µM, 56 Tested

AID:: 1947685

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 194768419.

Inhibition of recombinant human DYRK2 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scintillation counter analysis

Source:: ChEMBL

Assay data:37 Active, 20 Activity ≤ 1 µM, 56 Tested

AID:: 1947684

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 194768320.

Inhibition of recombinant human DYRK1B expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scintillation counter analysis

Source:: ChEMBL

Protein Target:: Dual specificity tyrosine-phosphorylation-regulated kinase 1B

Assay data:46 Active, 33 Activity ≤ 1 µM, 56 Tested

AID:: 1947683

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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BioActivity

Active Compounds (19)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (4)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (19)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Confirmatory (19)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

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Literature Extraction (27)
BioAssays extracted from the literature

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