BioAssays for PubChem Compound (Select 171344117) - PubChem BioAssay - NCBI

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Select item 19544831.

Inhibition of SRC (unknown origin) by Z'LYTE assay

Source:: ChEMBL

Protein Target:: Proto-oncogene tyrosine-protein kinase Src

Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested

AID:: 1954483

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19544822.

Inhibition of JAK3 (unknown origin) by Z'LYTE assay

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase JAK3

Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested

AID:: 1954482

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19544813.

Inhibition of HCK (unknown origin) by Z'LYTE assay

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase HCK

Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested

AID:: 1954481

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19544804.

Inhibition of EGFR (unknown origin) by Z'LYTE assay

Source:: ChEMBL

Protein Target:: Epidermal growth factor receptor

Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested

AID:: 1954480

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19544795.

Inhibition of ITK (unknown origin) by Z'LYTE assay

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase ITK/TSK

Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested

AID:: 1954479

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19544786.

Inhibition of BMX (unknown origin) by Z'LYTE assay

Source:: ChEMBL

Protein Target:: Cytoplasmic tyrosine-protein kinase BMX

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1954478

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19544777.

Inhibition of BLK (unknown origin) by Z'LYTE assay

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Blk

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1954477

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19544768.

Inhibition of BTK (unknown origin) by Z'LYTE assay

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase BTK

Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1954476

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19544669.

Covalent inhibition of NanoLuc fused BTK (unknown origin) expressed in HEK293 cells incubated for 90 mins by NanoBRET assay

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase BTK

Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested

AID:: 1954466

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 195446410.

Inhibition of BTK phosphorylation in human JeKo-1 cells at 0.01 to 10 uM incubated for 2 hrs by Western blot analysis

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase BTK

Assay data:2 Active, 2 Tested

AID:: 1954464

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 195446311.

Selectivity ratio, ratio of inhibition of BTK (unknown origin) assessed as ratio of Kinact/Ki to Inhibition of BMX (unknown origin) assessed as ratio of Kinact/Ki

Source:: ChEMBL

Assay data:3 Tested

AID:: 1954463

Summary PubMed Citation

Select item 195446212.

Selectivity ratio, ratio of inhibition of BTK (unknown origin) assessed as ratio of Kinact/Ki to Inhibition of BLK (unknown origin) assessed as ratio of Kinact/Ki

Source:: ChEMBL

Assay data:3 Tested

AID:: 1954462

Summary PubMed Citation

Select item 195446113.

Inhibition of BMX (unknown origin) assessed as ratio of Kinact/Ki

Source:: ChEMBL

Protein Target:: Cytoplasmic tyrosine-protein kinase BMX

Assay data:3 Tested

AID:: 1954461

Summary PubMed Citation Related BioAssays by Target

Select item 195446014.

Inhibition of BLK (unknown origin) assessed as ratio of Kinact/Ki

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Blk

Assay data:3 Tested

AID:: 1954460

Summary PubMed Citation Related BioAssays by Target

Select item 195445915.

Inhibition of BTK (unknown origin) assessed as ratio of Kinact/Ki

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase BTK

Assay data:3 Tested

AID:: 1954459

Summary PubMed Citation Related BioAssays by Target

Select item 195445816.

Selectivity ratio, ratio of IC50 for BTK (unknown origin) to IC50 for SRC (unknown origin)

Source:: ChEMBL

Assay data:2 Tested

AID:: 1954458

Summary PubMed Citation

Select item 195445717.

Selectivity ratio, ratio of IC50 for BTK (unknown origin) to IC50 for JAK3 (unknown origin)

Source:: ChEMBL

Assay data:3 Tested

AID:: 1954457

Summary PubMed Citation

Select item 195445618.

Selectivity ratio, ratio of IC50 for BTK (unknown origin) to IC50 for HCK (unknown origin)

Source:: ChEMBL

Assay data:3 Tested

AID:: 1954456

Summary PubMed Citation

Select item 195445519.

Selectivity ratio, ratio of IC50 for BTK (unknown origin) to IC50 for EGFR (unknown origin)

Source:: ChEMBL

Assay data:3 Tested

AID:: 1954455

Summary PubMed Citation

Select item 195445420.

Selectivity ratio, ratio of IC50 for BTK (unknown origin) to IC50 for ITK (unknown origin)

Source:: ChEMBL

Assay data:3 Tested

AID:: 1954454

Summary PubMed Citation

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BioActivity

Active Compounds (10)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (1)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (9)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Confirmatory (9)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

Depositor Category

Literature Extraction (22)
BioAssays extracted from the literature

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