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Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth measured after 72 hrs by MTS assay
Assay data:2 Active, 5 Tested
SummaryCompounds, ActivePubMed Citation
Antiproliferative activity against human LNCaP cells assessed as inhibition of cell growth measured after 72 hrs by MTS assay
Assay data:3 Active, 1 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Antiproliferative activity against human BT-549 cells assessed as inhibition of cell growth measured after 72 hrs by MTS assay
Assay data:5 Active, 1 Activity ≤ 1 µM, 5 Tested
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs by MTS assay
Assay data:3 Active, 5 Tested
PROTAC activity at CRBN/Wee1 in human LNCaP cells assessed as induction of Wee1 degradation by measuring reduction in CDK1 phosphorylation at Tyr15 residue at 300 nM and above concentrations measured after 4 hrs by Western blot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
PROTAC activity at CRBN/Wee1 in human LNCaP cells assessed as induction of Wee1 degradation at 300 nM and above concentrations measured after 4 hrs by Western blot analysis
PROTAC activity at CRBN/Wee1 in human BT-549 cells assessed as induction of Wee1 degradation by measuring reduction in CDK1 phosphorylation at Tyr15 residue at 300 nM and above concentrations measured after 4 hrs by Western blot analysis
PROTAC activity at CRBN/Wee1 in human MCF7 cells assessed as induction of Wee1 degradation at 300 nM and above concentrations measured after 4 hrs by Western blot analysis
PROTAC activity at CRBN/Wee1 in human BT-549 cells assessed as induction of Wee1 degradation by measuring reduction in CDK1 phosphorylation at Tyr15 residue at 100 nM and above concentrations measured after 4 hrs by Western blot analysis
PROTAC activity at CRBN/Wee1 in human BT-549 cells assessed as induction of Wee1 degradation at 100 nM and above concentrations measured after 4 hrs by Western blot analysis
PROTAC activity at CRBN/Wee1 in human PC-3 cells assessed as induction of Wee1 degradation by measuring reduction in CDK1 phosphorylation at Tyr15 residue at 100 nM and above concentrations measured after 4 hrs by Western blot analysis
PROTAC activity at CRBN/Wee1 in human PC-3 cells assessed as induction of Wee1 degradation at 100 nM and above concentrations measured after 4 hrs by Western blot analysis
PROTAC activity at CRBN/Wee1 in human HeLa S3 cells assessed as induction of Wee1 degradation at 1 uM pretreated with pomalidomide for 2 hrs followed by incubation with compound for 5 hrs by Western blot analysis
PROTAC activity at CRBN/Wee1 in human HeLa S3 cells assessed as induction of Wee1 degradation by measuring reduction in phosphorylation of CDK1 at Tyr15 residue at 1 uM pretreated with AZD1775 for 2 hrs followed by incubation with compound for 5 hrs by Western blot analysis
PROTAC activity at CRBN/Wee1 in human HeLa S3 cells assessed as induction of Wee1 degradation at 1 uM pretreated with AZD1775 for 2 hrs followed by incubation with compound for 5 hrs by Western blot analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
PROTAC activity at CRBN/Wee1 in human HeLa S3 cells assessed as induction of Wee1 degradation at 1 uM pretreated for 2 hrs with neddylation inhibitor MLN4924 followed by incubation with compound for 5 hrs by Western blot analysis
PROTAC activity at CRBN/Wee1 in human HeLa S3 cells assessed as induction of Wee1 degradation at 1 uM pretreated for 2 hrs with proteasome inhibitor MG132 followed by incubation with compound for 5 hrs by Western blot analysis
Induction of JAK2 degradation in human HeLa S3 cells at 1 uM measured for 24 to 48 hrs by Western blot analysis
Assay data:2 Tested
Induction of MAP3K4 degradation in human HeLa S3 cells at 1 uM measured for 24 to 48 hrs by Western blot analysis
Induction of PLK3 degradation in human HeLa S3 cells at 1 uM measured for 24 to 48 hrs by Western blot analysis
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