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Induction of apoptosis in human U-937 cells assessed as caspase-3 cleavage measured after 24 hrs by Western blot analysis
Assay data:1 Tested
SummaryPubMed Citation
Induction of apoptosis in human U-937 cells assessed as assessed as increase in PARP cleavage measured after 24 hrs by Western blot analysis
Inhibition of human BFL-1/PUMA protein-protein interaction in human Kasumi 1 cells assessed as decrease in PUMA protein level at 80 uM measured after 5 hrs by co-immunoprecipitation assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human BFL-1/PUMA protein-protein interaction in human Kasumi 1 cells assessed as increase in BFL-1 protein level at 20 to 80 uM measured after 5 hrs by co-immunoprecipitation assay
Upregulation of BFL-1 protein expression in human Raji cells by Western blotting analysis
Upregulation of BFL-1protein expression in human HL-60 cells by Western blotting analysis
Upregulation of BFL-1protein expression in human MV4-11 cells by Western blotting analysis
SummaryCompounds, ActivePubMed Citation
Upregulation of BFL-1protein expression in human MM1.S cells by Western blotting analysis
Upregulation of BFL-1protein expression in human K562 cells by Western blotting analysis
Upregulation of BFL-1protein expression in human RPMI-8226 cells by Western blotting analysis
Upregulation of BFL-1 protein expression in human U-937 cells by Western blotting analysis
Growth inhibition of human Raji cells incubated for 4 days by WST assay
Assay data:3 Tested
Growth inhibition of human HL-60 cells incubated for 4 days by WST assay
Growth inhibition of human RPMI-8226 cells incubated for 4 days by WST assay
Assay data:1 Active, 3 Tested
Growth inhibition of human MV4-11 cells incubated for 4 days by WST assay
Assay data:2 Active, 3 Tested
Growth inhibition of human K562 cells incubated for 4 days by WST assay
Growth inhibition of human Kasumi 1 cells incubated for 4 days by WST assay
Induction of apoptosis in human U-937 cells assessed as necrotic cells at 60 uM measured after 4 hrs by Annexin PI staining based flow cytometry method (Rvb = 0.00 %)
Assay data:2 Tested
Induction of apoptosis in human U-937 cells assessed as late apoptotic cells at 60 uM measured after 4 hrs by Annexin PI staining based flow cytometry method (Rvb = 1.62 %)
Induction of apoptosis in human U-937 cells assessed as necrotic cells at 40 uM measured after 4 hrs by Annexin PI staining based flow cytometry method (Rvb = 0.00 %)
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