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Inhibition of SREBP (unknown origin) expressed in HEK293 cells assessed as reduction in LDLr promotor activity after 24 hrs by luciferase reporter assay
Assay data:5 Active, 13 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Induction of human HMGCR-dCat-ELuc degradation expressed in HEK293 cells assessed as reduction in luciferase activity after 4 hrs by luciferase reporter assay
Assay data:9 Active, 2 Activity ≤ 1 µM, 13 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of gamma-crystallin D W43R mutant (unknown origin)-induced cytotoxicity in human HLE-B3 cells assessed as increase in cell viability at 0.04 to 4 uM incubated for 12 hrs by CCK8 assay
Assay data:5 Active, 5 Tested
Inhibition of gamma-crystallin D W43R mutant (unknown origin)-induced cytotoxicity in human HeLa cells assessed as increase in cell viability at 0.04 to 4 uM incubated for 12 hrs by CCK8 assay
Inhibition of gamma-crystallin C G129C mutant (unknown origin)-induced cytotoxicity in human HLE-B3 cells assessed as increase in cell viability at 0.04 to 4 uM incubated for 12 hrs by CCK8 assay
Assay data:5 Active, 6 Tested
Inhibition of gamma-crystallin C G129C mutant (unknown origin)-induced cytotoxicity in human HeLa cells assessed as increase in cell viability at 0.04 to 4 uM incubated for 12 hrs by CCK8 assay
Inhibition of beta-crystallin B2 V187E mutant (unknown origin)-induced cytotoxicity in human HLE-B3 cells assessed as increase in cell viability at 0.04 to 4 uM incubated for 12 hrs by CCK8 assay
Inhibition of beta-crystallin B2 V187E mutant (unknown origin)-induced cytotoxicity in human HeLa cells assessed as increase in cell viability at 0.04 to 4 uM incubated for 12 hrs by CCK8 assay
Inhibition of alpha-crystallin B R120G mutant (unknown origin)-induced cytotoxicity in human HLE-B3 cells assessed as increase in cell viability at 0.04 to 4 uM incubated for 12 hrs by CCK8 assay
Inhibition of alpha-crystallin B R120G mutant (unknown origin)-induced cytotoxicity in human HeLa cells assessed as increase in cell viability at 0.04 to 4 uM incubated for 12 hrs by CCK8 assay
Inhibition of alpha-crystallin A Y118D mutant (unknown origin)-induced cytotoxicity in human HLE-B3 cells assessed as increase in cell viability at 0.04 to 4 uM incubated for 12 hrs by CCK8 assay
Inhibition of alpha-crystallin A Y118D mutant (unknown origin)-induced cytotoxicity in human HeLa cells assessed as increase in cell viability at 0.04 to 4 uM incubated for 12 hrs by CCK8 assay
Increase in cell viability of human HLE-B3 cells transfected with peGFP-N1 at 0.04 to 4 uM incubated for 12 hrs by CCK8 assay
SummaryCompounds, ActivePubMed Citation
Increase in cell viability of human HeLa cells transfected with peGFP-N1 at 0.04 to 4 uM incubated for 12 hrs by CCK8 assay
Induction of redissolving of aggregated beta-crystallin B2 R188H mutant (unknown origin) at 200 uM incubated for 24 hrs by transmission-electron-microscopy
Assay data:1 Active, 2 Tested
Induction of redissolving of aggregated gamma-crystallin D W43R mutant (unknown origin) at 200 uM incubated for 24 hrs by transmission-electron-microscopy
Induction of redissolving of aggregated gamma-crystallin C G129C mutant (unknown origin) at 200 uM incubated for 24 hrs by transmission-electron-microscopy
Induction of redissolving of aggregated alpha-crystallin B R120G mutant (unknown origin) at 200 uM incubated for 24 hrs by transmission-electron-microscopy
Induction of redissolving of aggregated alpha-crystallin A Y118D mutant (unknown origin) at 200 uM incubated for 24 hrs by transmission-electron-microscopy
Induction of redissolving of aggregated alpha-crystallin A R116H mutant (unknown origin) at 200 uM incubated for 24 hrs by transmission-electron-microscopy
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