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mGlu5 Ca2+ Flux Assay from US Patent US10399948: "Negative allosteric modulators of metabotropic glutamate receptor 3"
Assay data:16 Active, 4 Activity ≤ 1 µM, 23 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
mGlu2 Ca2+ Flux Assay from US Patent US10399948: "Negative allosteric modulators of metabotropic glutamate receptor 3"
Assay data:55 Tested
SummaryRelated BioAssays by DepositorRelated BioAssays by Target
mGlu3 Ca2+ Flux Assay from US Patent US10399948: "Negative allosteric modulators of metabotropic glutamate receptor 3"
Assay data:46 Active, 21 Activity ≤ 1 µM, 60 Tested
Positive allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as increase in glutamate induced-calcium mobilization by measuring maximum glutamate response preincubated for 2.3 mins followed by glutamate addition measured for 1.9 mins by Fluo-4 AM dye based fluorescence assay relative to glutamate
Assay data:11 Tested
SummaryPubMed CitationRelated BioAssays by Target
Positive allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as increase in glutamate induced-calcium mobilization preincubated for 2.3 mins followed by glutamate addition measured for 1.9 mins by Fluo-4 AM dye based fluorescence assay
Assay data:11 Active, 3 Activity ≤ 1 µM, 13 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Negative allosteric modulation of rat mGlu3 receptor expressed in TREX cells coexpressing Galpha15 assessed as inhibition of glutamate induced-calcium mobilization by measuring minimum glutamate response preincubated for 2.3 mins followed by glutamate addition measured for 2.6 mins by Fluo-4 AM dye based fluorescence assay relative to glutamate
Assay data:13 Tested
Negative allosteric modulation of rat mGlu3 receptor expressed in TREX cells coexpressing Galpha15 assessed as inhibition of glutamate induced-calcium mobilization preincubated for 2.3 mins followed by glutamate addition measured for 2.6 mins by Fluo-4 AM dye based fluorescence assay
Assay data:12 Active, 9 Activity ≤ 1 µM, 14 Tested
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