BioAssays for PubChem Compound (Select 10836) - PubChem BioAssay - NCBI

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Select item 16714981.

Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging

Source:: ChEMBL

Assay data:2 Activity ≤ 1 µM, 4307 Tested

AID:: 1671498

Summary Compounds, activity ≤ 1 µM

Select item 14741672.

Liver toxicity in human assessed as induction of drug-induced liver injury by measuring verified drug-induced liver injury concern status

Source:: ChEMBL

Assay data:929 Tested

AID:: 1474167

Summary PubMed Citation

Select item 14741663.

Liver toxicity in human assessed as induction of drug-induced liver injury by measuring severity class index

Source:: ChEMBL

Assay data:929 Tested

AID:: 1474166

Summary PubMed Citation

Select item 14423994.

Induction of stimulus generalization in Sprague-Dawley rat trained to discriminate S(-)MCAT assessed as appropriate responding level to training drug by two lever method

Source:: ChEMBL

Assay data:5 Tested

AID:: 1442399

Summary PubMed Citation

Select item 14423985.

Induction of stimulus generalization in Sprague-Dawley rat trained to discriminate S(+)AMPH assessed as appropriate responding level to training drug by two lever method

Source:: ChEMBL

Assay data:5 Tested

AID:: 1442398

Summary PubMed Citation

Select item 14423746.

Induction of stimulus generalization in rat trained to discriminate S(+)methamphetamine assessed as appropriate responding level to training drug by two lever method

Source:: ChEMBL

Assay data:6 Tested

AID:: 1442374

Summary PubMed Citation

Select item 13238357.

Displacement of [3H]rosiglitazone from recombinant human C-terminal His-tagged MitoNEET cytosolic domain (32 to 108 residues) expressed in Escherichia coli BL21 by Cheng-Prusoff analysis

Source:: ChEMBL

Protein Target:: CDGSH iron-sulfur domain-containing protein 1

Assay data:57 Active, 48 Activity ≤ 1 µM, 86 Tested

AID:: 1323835

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 13238348.

Displacement of [3H]rosiglitazone from recombinant human C-terminal His-tagged MitoNEET cytosolic domain (32 to 108 residues) expressed in Escherichia coli BL21 by scintillation proximity assay

Source:: ChEMBL

Protein Target:: CDGSH iron-sulfur domain-containing protein 1

Assay data:40 Active, 9 Activity ≤ 1 µM, 86 Tested

AID:: 1323834

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 12332499.

Ratio of Ki for displacement of [3H]DTBZ from VMAT2 in rat whole brain to Ki for inhibition of VMAT2-mediated [3H]DA uptake in rat brain synaptic vesicles

Source:: ChEMBL

Protein Target:: Synaptic vesicular amine transporter

Assay data:6 Tested

AID:: 1233249

Summary PubMed Citation Related BioAssays by Target

Select item 123324710.

Inhibition of VMAT2-mediated [3H]DA uptake in rat brain synaptic vesicles by liquid scintillation spectrometry

Source:: ChEMBL

Protein Target:: Synaptic vesicular amine transporter

Assay data:6 Active, 5 Activity ≤ 1 µM, 6 Tested

AID:: 1233247

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 123324611.

Displacement of [3H]DTBZ from VMAT2 in rat whole brain by liquid scintillation spectrometry

Source:: ChEMBL

Protein Target:: Synaptic vesicular amine transporter

Assay data:5 Active, 5 Activity ≤ 1 µM, 6 Tested

AID:: 1233246

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 109733612.

Drug level in Homo sapiens (human) whole blood assessed as retention time by UPLC-TOF-MS analysis

Source:: ChEMBL

Assay data:175 Tested

AID:: 1097336

Select item 106637413.

Selectivity ratio of EC50 for rat TAAR1 transmembrane domain 6 Met268(6.55)Thr mutant to EC50 for rat wild type TAAR1

Source:: ChEMBL

Assay data:4 Tested

AID:: 1066374

Summary PubMed Citation

Select item 106637314.

Activation of rat TAAR1 Asp102(3.32)Ala mutant expressed in HEK293 cells assessed as stimulation of cAMP production at 0.0001 to 100 uM after 1 hr by chemiluminescent assay relative to control

Source:: ChEMBL

Protein Target:: Trace amine-associated receptor 1

Assay data:6 Tested

AID:: 1066373

Summary PubMed Citation Related BioAssays by Target

Select item 106637215.

Activation of mouse TAAR1 Asp102(3.32)Ala mutant expressed in HEK293 cells assessed as stimulation of cAMP production at 0.0001 to 100 uM after 1 hr by chemiluminescent assay

Source:: ChEMBL

Protein Target:: Trace amine-associated receptor 1

Assay data:6 Tested

AID:: 1066372

Summary PubMed Citation Related BioAssays by Target

Select item 106637116.

Activation of rat wild type TAAR1 expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr by chemiluminescent assay

Source:: ChEMBL

Protein Target:: Trace amine-associated receptor 1

Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested

AID:: 1066371

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 106637017.

Activation of mouse wild type TAAR1 expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr by chemiluminescent assay

Source:: ChEMBL

Protein Target:: Trace amine-associated receptor 1

Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested

AID:: 1066370

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 106636918.

Activation of rat TAAR1 transmembrane domain 6 Met268(6.55)Thr mutant expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr by chemiluminescent assay

Source:: ChEMBL

Protein Target:: Trace amine-associated receptor 1

Assay data:5 Active, 3 Activity ≤ 1 µM, 5 Tested

AID:: 1066369

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 106636819.

Activation of mouse TAAR1 transmembrane domain 6 Thr268(6.55)Met mutant expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr by chemiluminescent assay

Source:: ChEMBL

Protein Target:: Trace amine-associated receptor 1

Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested

AID:: 1066368

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 106636720.

Activation of rat TAAR1 transmembrane domain 7 Asn287(7.39)Tyr mutant expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr by chemiluminescent assay

Source:: ChEMBL

Protein Target:: Trace amine-associated receptor 1

Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested

AID:: 1066367

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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BioActivity

Active Compounds (27)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 µM (20)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Confirmatory (23)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

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Literature Extraction (72)
BioAssays extracted from the literature
Other (4)
BioAssays deposited by other experimentalists

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