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Determination of the Inhibitory Activity of the Compounds of the Present Invention on PARP1 Enzyme from US Patent US20240228490: "HETEROCYCLIC DERIVATIVE INHIBITOR AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF"
Assay data:36 Active, 14 Activity ≤ 1 nM, 36 Activity ≤ 1 µM, 36 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Enzyme Assay from US Patent US20240228460: "PROTEASE INHIBITORS AND METHODS OF MAKING SAME"
Assay data:3 Tested
SummaryRelated BioAssays by DepositorRelated BioAssays by Target
HIV RT Filter Binding IC50 Assay from US Patent US20240226130: "4'-THIONUCLEOSIDE ANALOGUES AND THEIR PHARMACEUTICAL USE"
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
BET BRD Assay from US Patent US20240226096: "TREATMENT OF MYELOPROLIFERATIVE DISEASES AND DISORDERS WITH INHIBITORS OF BET FAMILY BDII BROMODOMAIN"
Assay data:14 Active, 4 Activity ≤ 1 nM, 14 Activity ≤ 1 µM, 14 Tested
IRAK4 Kinase Assay from US Patent US12006303: "Substituted indazoles, methods for the production thereof, pharmaceutical preparations that contain said substituted indazoles, and use of said substituted indazoles to produce drugs"
Assay data:22 Active, 22 Activity ≤ 1 µM, 22 Tested
Enzyme Activity Assay from US Patent US12030897: "Pyrrolo[2,1-f][1,2,4]triazine derivatives serving as selective HER2 inhibitors and application thereof"
Assay data:15 Active, 15 Activity ≤ 1 µM, 15 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
In Vitro BRD4 (BD2) Enzymatic Activity Assay from US Patent US12030880: "Iminosulfanone compound as bromodomain protein inhibitor and pharmaceutical composition and medical use thereof"
Assay data:21 Active, 15 Activity ≤ 1 nM, 21 Activity ≤ 1 µM, 21 Tested
In Vitro BRD4 (BD1) Enzymatic Activity Assay from US Patent US12030880: "Iminosulfanone compound as bromodomain protein inhibitor and pharmaceutical composition and medical use thereof"
Assay data:21 Active, 2 Activity ≤ 1 nM, 21 Activity ≤ 1 µM, 21 Tested
Fluorescence Polarization Assay from US Patent US12030867: "Hsp90β selective inhibitors"
Assay data:17 Active, 15 Activity ≤ 1 µM, 18 Tested
Fluorescence Polarization Assay from US Patent US20240218021: "CYCLIN INHIBITORS"
Assay data:676 Active, 672 Activity ≤ 1 µM, 677 Tested
ERα TR-FRET Test from US Patent US20240217988: "ESTROGEN RECEPTOR ANTAGONIST"
Assay data:14 Active, 14 Activity ≤ 1 µM, 14 Tested
BTK Kinase Assay from US Patent US20240217973: "IMIDAZOPYRIDINE COMPOUNDS AND USE THEREOF"
Assay data:12 Active, 1 Activity ≤ 1 nM, 12 Activity ≤ 1 µM, 12 Tested
Receptor Binding Assay from US Patent US12023331: "Methods"
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Biochemical Potency on JAK1, JAK2, JAK3 and Tyk2 from US Patent US20240209001: "HETEROCYCLIC DERIVATIVES AS JANUS KINASE INHIBITORS"
Assay data:10 Active, 10 Activity ≤ 1 µM, 10 Tested
Surface Plasmon Resonance (SPR) Biosensor Assay from US Patent US20240208970: "SUBSTITUTED HYDANTOIN COMPOUNDS, METHODS FOR PREPARATION THEREOF AND USE THEREOF IN THE TREATMENT AND/OR PREVENTION OF A CORONA VIRUS DISEASE"
Assay data:15 Active, 15 Activity ≤ 1 µM, 16 Tested
SARS-CoV-2 Mpro Protease Enzyme Assay from US Patent US20240208970: "SUBSTITUTED HYDANTOIN COMPOUNDS, METHODS FOR PREPARATION THEREOF AND USE THEREOF IN THE TREATMENT AND/OR PREVENTION OF A CORONA VIRUS DISEASE"
Assay data:76 Active, 51 Activity ≤ 1 µM, 79 Tested
In Vitro Enzyme IC50 Assay from US Patent US20240207292: "BORONIC ACID COMPOUNDS, COMPOSITIONS AND METHODS"
Assay data:93 Active, 7 Activity ≤ 1 nM, 93 Activity ≤ 1 µM, 93 Tested
PI3K Biochemical Assay from US Patent US20240207263: "SELECTIVE MODULATORS OF ATAXIA TELANGIECTASIA MUTATED (ATM) KINASE AND USES THEREOF"
Assay data:12 Tested
PTPN2 Biochemical Assay from US Patent US20240207238: "INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE, COMPOSITIONS, AND METHODS OF USE"
Assay data:10 Active, 1 Activity ≤ 1 nM, 10 Activity ≤ 1 µM, 10 Tested
PhosphoSens Assay from US Patent US20240207238: "INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE, COMPOSITIONS, AND METHODS OF USE"
Assay data:9 Active, 1 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 9 Tested
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