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Conditioned place preference (CPP) assay from US Patent US20240252496: "SELECTIVE HYPOTHALAMUS PERMEABLE HDAC6 INHIBITORS FORTREATMENT OF LEPTIN-RESISTANT OBESITY"
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
In Vitro Assay from US Patent US20240150300: "S-CONFIGURATION-CONTAINING AMINO BENZAMIDE PYRIDAZINONE COMPOUND, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF"
Assay data:22 Active, 22 Activity ≤ 1 µM, 22 Tested
Inhibition of full length C-terminal His/FLAG tagged human recombinant HDAC1 (1 to 482 residues) expressed in baculovirus-infected Sf9 cells using RHK-K(Ac)-AMC as substrate incubated for 2 hrs
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of HDAC in human HeLa nuclear extract assessed as residual activity at 20 uM relative to control
Assay data:16 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of HDAC in human HCT-116 cells assessed as increase in alpha tubulin acetylation at 1 uM incubated for 24 hrs by Western blot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of HDAC in human HCT-116 cells assessed as increase in histone H3 acetylation at 1 uM incubated for 24 hrs by Western blot analysis
Inhibition of HDAC in human HCT-116 cells assessed as increase in alpha tubulin acetylation incubated for 24 hrs by Western blot analysis
Assay data:1 Tested
Inhibition of HDAC in human HCT-116 cells assessed as increase in histone H3 acetylation incubated for 24 hrs by Western blot analysis
Inhibition of HDAC4 (unknown origin)
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of HDAC3 (unknown origin)
Inhibition of HDAC2 (unknown origin)
Inhibition of HDAC1 (unknown origin)
Inhibition of HDAC in human HeLa nuclear extract at 0.1 uM using Boc-Lys(Ac)-AMC or Boc-Lys(Tfa)-AMC as substrate preincubated for 5 mins followed by substrate addition and measured after 30 mins by fluorescence assay
Assay data:9 Tested
Inhibition of HDAC2 (unknown origin) using Boc-Lys(Ac)-AMC or Boc-Lys(Tfa)-AMC as substrate preincubated for 5 mins followed by substrate addition and measured after 1 hr by fluorescence assay
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Inhibition of HDAC1 (unknown origin) using Boc-Lys(Ac)-AMC or Boc-Lys(Tfa)-AMC as substrate preincubated for 5 mins followed by substrate addition and measured after 2 hrs by fluorescence assay
Inhibition of HDAC in human HeLa nuclear extract using Boc-Lys(Ac)-AMC or Boc-Lys(Tfa)-AMC as substrate preincubated for 5 mins followed by substrate addition and measured after 30 mins by fluorescence assay
Assay data:11 Active, 11 Activity ≤ 1 µM, 11 Tested
Inhibition of HDAC in human HeLa nuclear extract at 0.1 uM using Boc-Lys(Ac)-AMC or Boc-Lys(Tfa)-AMC as substrate preincubated for 5 mins followed by substrate addition and measured after 30 mins by fluorescence assay relative to control
Assay data:30 Tested
Inhibition of HDAC in human HepG2 cells assessed as increase in histone H3 acetylation at 5 uM incubated for 24 hrs by Western blot analysis
Inhibition of HDAC in human Huh-7 cells assessed as increase in histone H3 acetylation at 5 uM incubated for 24 hrs by Western blot analysis
Inhibition of HDAC in human HepG2 cells assessed as increase in histone H3 acetylation at 20 uM incubated for 24 hrs by Western blot analysis
Assay data:1 Active, 2 Tested
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