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Assay for Inhibition of MMP from US Patent US20240050571: "CARBORANE HYDROXAMIC ACID MATRIX METALLOPROTEINASE INHIBITORS AND AGENTS FOR BORON NEUTRON CAPTURE THERAPY"
Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of MMP-2 in mouse fibroblast assessed as reduction in concanavalin-induced MMP-2 activity by measuring gelatin digestion incubated for 24 hrs by SDS-PAGE gel electrophoresis based gelatin zymography analysis
Assay data:3 Active, 3 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of MMP-2 (unknown origin) using QXL520-gamma-Abu-Pro-Cha-Abu-Smc-His-Ala-Dab(5-FAM)-Ala-Lys-NH2 as fluorogenic substrate at 100 uM preincubated for 10 mins followed by substrate addition and measured for 25 mins by microplate reader assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of MMP-13 (unknown origin) using QXL520-gamma-Abu-Pro-Cha-Abu-Smc-His-Ala-Dab(5-FAM)-Ala-Lys-NH2 as fluorogenic substrate at 100 uM preincubated for 10 mins followed by substrate addition and measured for 25 mins by microplate reader assay
Inhibition of MMP-9 (unknown origin) using QXL520-gamma-Abu-Pro-Cha-Abu-Smc-His-Ala-Dab(5-FAM)-Ala-Lys-NH2 as fluorogenic substrate at 100 uM preincubated for 10 mins followed by substrate addition and measured for 25 mins by microplate reader assay
Inhibition of MMP-13 (unknown origin) using QXL520-gamma-Abu-Pro-Cha-Abu-Smc-His-Ala-Dab(5-FAM)-Ala-Lys-NH2 as fluorogenic substrate at 1 to 100 uM preincubated for 10 mins followed by substrate addition and measured for 25 mins by microplate reader assay
Inhibition of MMP-9 (unknown origin) using QXL520-gamma-Abu-Pro-Cha-Abu-Smc-His-Ala-Dab(5-FAM)-Ala-Lys-NH2 as fluorogenic substrate at 1 to 100 uM preincubated for 10 mins followed by substrate addition and measured for 25 mins by microplate reader assay
Inhibition of MMP-2 (unknown origin) using QXL520-gamma-Abu-Pro-Cha-Abu-Smc-His-Ala-Dab(5-FAM)-Ala-Lys-NH2 as fluorogenic substrate at 1 to 100 uM preincubated for 10 mins followed by substrate addition and measured for 25 mins by microplate reader assay
Assay data:2 Tested
Inhibition of MMP-13 (unknown origin) using QXL520-gamma-Abu-Pro-Cha-Abu-Smc-His-Ala-Dab(5-FAM)-Ala-Lys-NH2 as fluorogenic substrate preincubated for 10 mins followed by substrate addition and measured for 25 mins by microplate reader assay
Inhibition of MMP-9 (unknown origin) using QXL520-gamma-Abu-Pro-Cha-Abu-Smc-His-Ala-Dab(5-FAM)-Ala-Lys-NH2 as fluorogenic substrate preincubated for 10 mins followed by substrate addition and measured for 25 mins by microplate reader assay
Inhibition of MMP-14 (unknown origin) using 5-FAM-TDVPNGFHVS (QXL520)-NH2 as fluorogenic substrate at 12.5 to 200 uM preincubated for 10 mins followed by substrate addition and measured for 50 mins by microplate reader assay
Binding affinity to CMS sensor chip immobilized MMP-14 catalytic domain (unknown origin) assessed as equilibrium dissociation constant by surface plasmon resonance analysis
Assay data:2 Active, 2 Tested
Inhibition of MMP-14 (unknown origin) using 5-FAM-TDVPNGFHVS (QXL520)-NH2 as fluorogenic substrate preincubated for 10 mins followed by substrate addition and measured for 50 mins by microplate reader assay
Assay data:3 Tested
Inhibition of MMP-14 (unknown origin) using 5-FAM-TDVPNGFHVS (QXL520)-NH2 as fluorogenic substrate at 47.6 uM preincubated for 10 mins followed by substrate addition by primary HTS analysis relative to control
Assay data:1 Active, 3 Tested
Inhibition of MMP-9 (unknown origin) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 30 mins followed by substrate addition by fluorometric assay
Assay data:4 Tested
Inhibition of MMP-3 (unknown origin) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate incubated for 30 mins by fluorometric assay
Inhibition of MMP-2 (unknown origin) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 30 mins followed by substrate addition by fluorometric assay
Inhibition of MMP-2 (unknown origin) using succinylated gelatin as substrate incubated for 80 mins by microplate reader
Assay data:1 Active, 1 Tested
Inhibition of MMP-9 (unknown origin)
Inhibition of MMP-3 (unknown origin)
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