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PDGFRA Invitrogen Lab (UK) kinase screen (BI)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of PDGFRa (unknown origin) at 10 uM by biochemical hotspot kinase assay
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of PDGFRalpha (unknown origin) preincubated for 60 mins followed by ATP addition and measured after 1 hr by ADP-Glo assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of PDGFRalpha (unknown origin) assessed as residual activity at 1 uM preincubated for 60 mins followed by ATP addition and measured after 1 hr by ADP-Glo assay relative to control
Inhibition of PDGFRalpha (unknown origin) at 1 uM relative to control
Inhibition of GST-tagged human recombinant PDGFR-alpha (550 to 1089 residues) expressed in baculovirus expression system at 200 nM by Z'-lyte assay
Inhibition of PDGFRalpha (unknown origin) incubated for 1.5 hrs in the presence of ATP by Z'-LYTE kinase assay
Inhibition of recombinant PDGFRalpha (unknown origin) incubated for 60 mins by ELISA analysis
Inhibition of PDGFRalpha (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of PDGFRalpha D842V mutant (unknown origin)
Kinase (PDGFRα, PDGFRβ, ABL1 and FLT3) Inhibition Test of Compounds from US Patent US20230312529: "PYRIMIDINE SMALL-MOLECULE COMPOUND AND APPLICATION THEREOF"
Assay data:13 Active, 13 Activity ≤ 1 µM, 13 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
PDGFRα Kinase Assay from US Patent US11679110: "Methods of treating disorders using CSF1R inhibitors"
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Enzyme-linked immunosorbent assay (ELISA) from US Patent US11655239: "Fused ring pyrimidine amino compound and preparation method, pharmaceutical composition, and use thereof"
Assay data:32 Active, 18 Activity ≤ 1 nM, 32 Activity ≤ 1 µM, 32 Tested
Kinase Activity Assay from US Patent US11591328: "Highly active CSF1R inhibitor compound"
Selectivity interaction (Kinase Profiler (Millipore)) EUB0000603a PDGFRA
Selectivity interaction (NanoBRET assay (HEK293T cells)) EUB0000321b PDGFRA
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000321b PDGFRA
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