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Inhibition of human recombinant CDC25C
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of recombinant N-terminal GST-tagged CDC25C (unknown origin) expressed in Escherichia coli BL21 (DE3) cells incubated for 2 hrs
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human CDC25C
Assay data:2 Active, 2 Tested
Inhibition of recombinant CDC25C (unknown origin)
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of CDC25C (unknown origin)
Assay data:7 Active, 7 Tested
Inhibition of cdc25c in human HCC1806 cells assessed as increase in cdc25c phosphorylation at ser216 residue by western blot analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of CDC25C (unknown origin) assessed as change in enzyme activity at 150 uM using OMFP substrate incubated for 15 mins relative to control
SummaryRelated BioAssays by Target
Inhibition of recombinant human Cdc25C at 10 uM using OMFP as substrate preincubated for 5 to 8 mins and measured every 5 mins 60 mins by fluorescence based assay
Assay data:4 Active, 4 Tested
Inhibition of recombinant human Cdc25C using OMFP as substrate preincubated for 5 to 8 mins and measured every 5 mins 60 mins by fluorescence based assay
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Potency index, ratio of IC50 of NSC663284 to IC50 of compound for inhibition of recombinant human Cdc25C using OMFP as substrate preincubated for 5 to 8 mins and measured every 5 mins 60 mins by fluorescence based assay
Inhibition of N-terminal His6-tagged human CDC25C (280 to 454 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as substrate by double reciprocal Lineweaver-Burk plot analysis
Assay data:3 Active, 1 Activity ≤ 1 µM, 3 Tested
Inhibition of CDC25C in human A431 cells assessed as increase in CDK-mediated phosphorylation of histone H3 at Ser10 residues at 10 to 50 uM after 24 hrs by Western blot analysis
Inhibition of CDC25C in human A431 cells assessed as decrease in CDK-mediated phosphorylation of histone H3 at Ser10 residues at 50 uM after 24 hrs by Western blot analysis
Inhibition of CDC25C in human A431 cells assessed as increase in CDK-mediated phosphorylation of histone H3 at Ser10 residues at 10 uM after 24 hrs by Western blot analysis
Inhibition of CDC25C in human A431 cells assessed as increase in phosphorylation of CDK1 at Thr14/Tyr15 residues at 50 uM after 24 hrs by Western blot analysis
Assay data:1 Active, 2 Tested
Inhibition of recombinant human full length GST-tagged CDC25C expressed in Escherichia coli BL21-DE3 pLysS using 3-O-methylfluorescein phosphate as substrate after 2 hrs by fluorimetric analysis
Assay data:18 Active, 9 Activity ≤ 1 µM, 19 Tested
Induction of cdc25c phosphorylation in human MCF7 cells after 48 hrs by Western blot method
Inhibition of cdc25c phosphorylation in human HeLa cells at 0.1 to 1 uM after 24 to 48 hrs by Western blot analysis
Inhibition of human recombinant full length GST-tagged CDC25C transfected in Escherichia coli BL21-DE3 using 3-O-methylfluorescein phosphate as substrate at 10 uM incubated for 20 mins followed by substrate addition measured every 10 mins for 2 hrs by fluorimetric assay
Assay data:8 Tested
Inhibition of human CDC25C phosphatase
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