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Inactivation of BRCA1 in human DU145 cells assessed as decline in BRCA1 phosphorylation at Ser1524 at 20 uM by western blot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inactivation of BRCA1 in human PC3 cells assessed as decline in BRCA1 phosphorylation at Ser1524 at 20 uM after 8 hrs by western blot analysis
Displacement of phospho-BACH1 protein from BRCT domain of BRCA1 at 0.5 to 5000 uM by PAGE analysis
Assay data:2 Active, 2 Tested
Inhibition of BRCT domain of His-tagged BRCA1 after 1 min by competitive fluorescence polarization assay
Assay data:12 Active, 8 Activity ≤ 1 µM, 15 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression
Assay data:3980 Active, 755 Activity ≤ 1 µM, 377550 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression: Summary
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Binding affinity to BRCA1 by isothermal titration calorimetric assay
Assay data:6 Active, 3 Activity ≤ 1 µM, 6 Tested
Inhibition of BRCA1 by fluorescence polarization assay
Assay data:5 Active, 1 Activity ≤ 1 µM, 19 Tested
Dose Response confirmation of Inhibitors of Mdm2/MdmX interaction using a Brca1/Bard1 BiLC Counterscreen assay
Assay data:20 Active, 2 Activity ≤ 1 µM, 20 Tested
Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Brca1/Bard1 BiLC Counterscreen assay.
Assay data:5683 Active, 6242 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Inhibition of BRCA1 assessed as BRCT-BACH1 interaction
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
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