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Safety47 Scan (DiscoverX - Eurofins)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Muscarinic M3 Eurofins Panlabs panel
M3/H Eurofins SafetyScreen44 (BI)
M3(H)AGON Eurofins SafetyScreen44 (BI)
M3(H)ANTAG Eurofins SafetyScreen44 (BI)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Binding affinity towards human CHRM3 in an in vitro assay with cellular components measured by scintillation proximity assay
Assay data:93 Active, 1 Activity ≤ 1 nM, 42 Activity ≤ 1 µM, 1188 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Displacement of [3H]4-DAMP from human recombinant M3 receptor at 10 uM after 60 mins by scintillation counting analysis relative to control
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Agonist activity at C-terminal NanoLuc tagged human muscarinic M3 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M3 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation at 100 uM preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay
Assay data:4 Tested
Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M3 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay
Assay data:2 Active, 6 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Partial agonist activity at C-terminal NanoLuc tagged human muscarinic M3 receptor expressed in HEK293T cells using furimazine as substrate assessed as receptor activation by measuring maximum efficacy preincubated with substrate for 1 min followed by compound addition and measured for 6 mins 27 sec by NanoBRET assay relative to control
Assay data:6 Tested
Binding affinity to human muscarinic M3 receptor expressed in CHO cells assessed as binding to cell membrane at 60 nM measured for 60 mins in presence of atropine by Hoechst H33342 staining based confocal microscopy
Assay data:2 Tested
Binding affinity to human muscarinic M3 receptor expressed in CHO cells assessed as binding to cell membrane at 100 nM measured for 60 mins in presence of atropine by Hoechst H33342 staining based confocal microscopy
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