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Agonistic Activity Assay from US Patent US9253997: "Alkylamine derivative"
Assay data:30 Active, 15 Activity ≤ 1 µM, 33 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Calcium-Sensing Receptor Antagonist Fluorescence Assay from Article 10.1021/jm801178c: "Discovery and Structure-Activity Relationships of Trisubstituted Pyrimidines/Pyridines as Novel Calcium-Sensing Receptor Antagonists."
Assay data:30 Active, 21 Activity ≤ 1 µM, 44 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
PRESTO-Tango GPCRome screening (CASR)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Antagonist activity at human CaSR in human HEK293 cells measured after 5 mins by FLIPR assay
Assay data:7 Active, 7 Activity ≤ 1 µM, 8 Tested
Antagonist activity at mouse CaSR
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Agonist activity at CaSR in rat parathyroid cells assessed as inhibition of PTH (1 to 84 residues) production in presence of Cacl2 by ELISA
Assay data:13 Active, 2 Activity ≤ 1 nM, 14 Activity ≤ 1 µM, 15 Tested
Agonist activity at human CaSR expressed in CHO cells assessed as increase in intracellular calcium mobilization after 1 hr by Fura-2 dye-based fluorescence assay
Assay data:16 Active, 14 Activity ≤ 1 µM, 16 Tested
Binding affinity to human CaSR expressed in HEK293 cells after 30 mins in presence of NPS 568 by liquid scintillation counting method
SummaryPubMed CitationRelated BioAssays by Target
Agonist activity at rat CaSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by fluo-4AM dye based FLIPR assay
Agonist activity at mouse CaSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by fluo-4AM dye based FLIPR assay
Agonist activity at human CaSR expressed in HEK293 cells assessed as increase in intracellular calcium mobilization by fluo-4AM dye based FLIPR assay
Assay data:20 Active, 18 Activity ≤ 1 µM, 20 Tested
Inhibition of human calcium sensing receptor expressed in HEK293 cells assessed as decrease in calcium flux at 10 uM by fluorometric method relative to control
Rat CaS receptor (Calcium-sensing receptor)
Assay data:5 Active, 5 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Human CaS receptor (Calcium-sensing receptor)
Assay data:17 Active, 17 Tested
Mouse CaS receptor (Calcium-sensing receptor)
Assay data:1 Active, 1 Tested
Antagonist activity at calcium sensing receptor (unknown origin) by cell based FLIPR assay
Assay data:20 Active, 19 Activity ≤ 1 µM, 21 Tested
Agonist activity at rat brain CaSR expressed in CHO cells assessed as inositol phosphate production in presence of 3 mM extracellular Ca2+ by IP-one assay
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
Agonist activity at rat brain CaSR expressed in CHO cells assessed as inositol phosphate production at 0.1 uM in presence of 3 mM extracellular Ca2+ by IP-one assay
Agonist activity at rat brain CaSR expressed in CHO cells assessed as inositol phosphate production at 3 uM in presence of 2 mM extracellular Ca2+ by IP-one assay
Assay data:6 Tested
Agonist activity at rat brain CaSR expressed in CHO cells assessed as inositol phosphate production at 10 uM in presence of 2 mM extracellular Ca2+ by IP-one assay
Assay data:10 Tested
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