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GTP-KRAS and cRAF Interaction Assay from US Patent US20240199644: "Fused Ring Derivatives Useful as KRAS G12D Inhibitors"
Assay data:16 Active, 4 Activity ≤ 1 nM, 15 Activity ≤ 1 µM, 16 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Surface Plasmon Resonance Assay from US Patent US20240197735: "METHODS AND COMPOSITIONS COMPRISING A BRAF INHIBITOR AND A PD-1 BINDING ANTAGONIST"
Assay data:4 Active, 2 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
Kinase Assay from US Patent US20240174621: "METHYLQUINAZOLINONE DERIVATIVES"
Assay data:5 Active, 3 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 5 Tested
Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) from US Patent US20240150366: "4-AMINOQUINAZOLINE COMPOUND"
Assay data:21 Active, 21 Activity ≤ 1 µM, 21 Tested
BRAF-Inhibiting Assay from US Patent US11964950: "Arylamide derivative having antitumor activity"
Assay data:175 Active, 5 Activity ≤ 1 nM, 174 Activity ≤ 1 µM, 175 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
BRAF SGC Tm panel (DSF)
Assay data:1 Tested
SummaryRelated BioAssays by Target
RAF1 Invitrogen Lab (UK) kinase screen (BI)
Inhibition of c-RAF (unknown origin) at 10 uM by biochemical hotspot kinase assay relative to control
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of B-RAF (unknown origin) at 10 uM by biochemical hotspot kinase assay relative to control
Protac activity at E3 ubiquitin ligase/BRAF in human EA.hy 926 cells assessed as degradation of BRAF protein at 30 uM preincubated with S5 for 2 hrs followed by compound addition and measured after 48 hrs by Western blot analysis
Protac activity at E3 ubiquitin ligase/BRAF in human EA.hy 926 cells assessed as degradation of BRAF protein at 30 uM preincubated with VH032 for 2 hrs followed by compound addition and measured after 48 hrs by Western blot analysis
Protac activity at E3 ubiquitin ligase/BRAF in human MDA-MB-231 cells assessed as degradation of BRAF protein
Protac activity at E3 ubiquitin ligase/BRAF in human U87 cells assessed as degradation of BRAF protein
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Protac activity at E3 ubiquitin ligase/BRAF in human HepG2 cells assessed as degradation of BRAF protein
Protac activity at E3 ubiquitin ligase/BRAF in human EA.hy 926 cells assessed as degradation of BRAF protein at 40 uM incubated for 4 to 48 hrs by western blot assay
Protac activity at E3 ubiquitin ligase/BRAF in human EA.hy 926 cells assessed as degradation of BRAF protein at 40 uM incubated for 48 hrs by western blot assay
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