Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
THR/RXR Heterodimer Assay for Thyroid Hormone Receptor Agonist Screening from US Patent US20240059682: "THYROID HORMONE RECEPTOR BETA AGONIST COMPOUNDS"
Assay data:26 Active, 25 Activity ≤ 1 µM, 26 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay for Thyroid Hormone Receptor Agonist Screening from US Patent US20240059682: "THYROID HORMONE RECEPTOR BETA AGONIST COMPOUNDS"
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
THR Reporter Gene Method from US Patent US20240059676: "THYROID HORMONE RECEPTOR b SELECTIVE AGONIST COMPOUND, PHARMACEUTICAL COMPOSITION AND USE THEREOF"
Assay data:32 Active, 21 Activity ≤ 1 µM, 38 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Agonist activity at human THRbeta transfected in Huh7 cells co-transfected with luciferase reporter plasmid assessed as reduction in luciferase activity incubated for 16 hrs by Steady-Glo luciferase assay
Assay data:15 Active, 15 Activity ≤ 1 µM, 20 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at human THRalpha transfected in Huh7 cells co-transfected with luciferase reporter plasmid assessed as reduction in luciferase activity incubated for 16 hrs by Steady-Glo luciferase assay
Assay data:15 Active, 1 Activity ≤ 1 nM, 13 Activity ≤ 1 µM, 20 Tested
Inverse agonist activity at human THRB expressed in CHO cells co-expressing GAL4-NHR-LBD assessed as transcriptional repression preincubated for 6 hrs followed by luciferin addition by luminescence method
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inverse agonist activity at human THRA expressed in CHO cells co-expressing GAL4-NHR-LBD assessed as transcriptional repression preincubated for 6 hrs followed by luciferin addition by luminescence method
Binding affinity to human TR alpha LBD assessed as change in melting temperature at 10 uM by thermal shift assay
Assay data:6 Tested
Agonist activity at human TR beta LBD (202 to 461 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as induction of N-terminal biotinylated coactivator SRC2-3 peptide recruitment by alphascreen assay relative to control
Assay data:9 Tested
Agonist activity at wild type human TR alpha LBD expressed in Escherichia coli BL21 (DE3) assessed as induction of N-terminal biotinylated coactivator SRC2-3 peptide recruitment by alphascreen assay relative to control
Assay data:2 Tested
Binding affinity to human TR beta LBD (202 to 461 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as change in melting temperature at 10 uM in presence of ZnSO4 by thermal shift assay
Assay data:10 Tested
Agonist activity at human TR beta LBD (202 to 461 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as induction of N-terminal biotinylated coactivator SRC2-3 peptide recruitment by alphascreen assay
Assay data:28 Active, 28 Activity ≤ 1 µM, 32 Tested
Agonist activity at wild type human TR alpha LBD expressed in Escherichia coli BL21 (DE3) assessed as induction of N-terminal biotinylated coactivator SRC2-3 peptide recruitment by alphascreen assay
Assay data:21 Active, 20 Activity ≤ 1 µM, 28 Tested
Agonist activity at human THR-beta expressed in CHO-K1 cells by PathHunter assay
Agonist activity at human THR-alpha expressed in CHO-K1 cells by PathHunter assay
Agonist activity at human THR-alpha expressed in CHO-K1 cells assessed as maximum relative efficacy at 100 uM by PathHunter assay relative to control
Assay data:1 Tested
Agonist activity at human THR-beta expressed in CHO-K1 cells assessed as maximum relative efficacy at 100 uM by PathHunter assay relative to triiodothyronine ine
THYROID HORM Eurofins SafetyScreen44 (BI)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Agonist activity at human THbeta (202 to 461 residues) in Cos7 cells transfected with LBD-Gal4 and pGL435 Gal4 UAS Luc reporter plasmid at 10 uM by reporter gene assay
Target Selectivity Assays from US Patent US20240041837: "TRIAZOLONE COMPOUNDS AND USES THEREOF"
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on