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Panlabs assay PDE1A
Assay data:1 Tested
SummaryRelated BioAssays by Target
3H-cAMP and 3H-cGMP Scintillation Proximity Assay (PDE1)
Assay data:1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of PDE1 (unknown origin)
Assay data:2 Active, 2 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human PDE1C
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human PDE1B
Inhibition of recombinant full length PDE1B in human myocardium using cAMP as substrate
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of recombinant full length PDE1C in human myocardium stimulated by calmodulin using cGMP as substrate at 1 uM
Inhibition of recombinant full length PDE1C in human myocardium stimulated by calmodulin using cAMP as substrate at 1 uM
Inhibition of recombinant full length PDE1C in human myocardium using cGMP as substrate at 1 uM
Inhibition of recombinant full length PDE1C in human myocardium using cAMP as substrate at 1 uM
Inhibition of PDE1B (unknown origin)
Inhibition of PDE1C (unknown origin)
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
PDE1 Inhibition Assay from US Patent US11634416: "Combination treatments comprising administration of 1H-pyrazolo[4,3-b]pyridines"
Assay data:192 Active, 70 Activity ≤ 1 nM, 192 Activity ≤ 1 µM, 192 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
PDE1 Inhibition Assay from US Patent US11608342: "PDE9 inhibitors with imidazo triazinone backbone and imidazo pyrazinone backbone for treatment of peripheral diseases"
Assay data:4 Active, 5 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition Assay from US Patent US11535611: "Pyrazolo[3,4-B]pyridines and imidazo[1,5-B]pyridazines as PDE1 inhibitors"
Assay data:85 Active, 70 Activity ≤ 1 µM, 85 Tested
PDE1 Inhibition Assay from US Patent US11491140: "1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors"
Assay data:196 Active, 73 Activity ≤ 1 nM, 196 Activity ≤ 1 µM, 196 Tested
Selectivity interaction (PDE panel (enzymatic activity assay)) EUB0000751a PDE1A
Selectivity interaction (PDE panel (enzymatic assay)) EUB0000744a PDE1A
Inhibition of PDE1B (10 to 487 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cGMP as substrate measured for 15 mins by liquid scintillation counter method
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
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