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Inhibition of endoplasmic reticulum stress-induced CHOP activity in rat INS-1 cells assessed as restoration of tunicamycin-mediated reduction of 20 mM glucose-stimulated insulin secretion preincubated for 24 hrs followed by glucose addition and subsequent incubation for 45 mins by ELISA
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of endoplasmic reticulum stress-induced CHOP activity in mouse BetaTC6 cells assessed as decrease in tunicamycin-induced cell death by measuring cell viability at 2.5 to 20 uM after 72 hrs by CellTiter-Glo assay
Inhibition of endoplasmic reticulum stress-induced CHOP activity in rat INS-1 cells assessed as decrease in sodium palmitate-induced cell death by measuring cell viability at 2.5 to 20 uM after 72 hrs by CellTiter-Glo assay
Inhibition of endoplasmic reticulum stress-induced CHOP activity in rat INS-1 cells assessed as decrease in brefeldin A-induced cell death by measuring cell viability at 5 to 20 uM after 72 hrs by CellTiter-Glo assay
Inhibition of endoplasmic reticulum stress-induced CHOP activity in rat INS-1 cells assessed as suppression of tunicamycin-induced caspase-3 cleavage at 20 uM after 2 to 24 hrs by Western blot method
Inhibition of endoplasmic reticulum stress-induced CHOP activity in rat INS-1 cells assessed as suppression of tunicamycin-induced PARP cleavage at 20 uM after 2 to 24 hrs by Western blot method
Inhibition of endoplasmic reticulum stress-induced CHOP activity in tunicamycin-treated rat INS-1 cells assessed as DNA fragmentation at 20 uM after 24 hrs by TUNEL assay (Rvb = 15%)
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of endoplasmic reticulum stress-induced CHOP activity in tunicamycin-treated C57BL/6 mouse primary pancreatic islet beta cells assessed as DNA fragmentation at 10 uM after 24 hrs by TUNEL assay (Rvb = 40.4%)
Induction of CHOP (unknown origin) expressed in CHOK1 cells by luciferase reporter gene assay
Assay data:14 Active, 8 Activity ≤ 1 µM, 25 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Medium Throughput Quantitative RT-PCR for CHOP Gene Expression
Assay data:11 Tested
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Late-stage results from the probe development effort to identify transcriptional activators of heat shock protein 70 (Hsp70): fluorescence-based biochemical quantitative polymerase chain reaction assay to assess gene expression changes in downstream target genes
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
CHOP Confirmatory Screen
Assay data:940 Active, 2091 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
CHOP dose-response primary assay
Assay data:334 Active, 70 Activity ≤ 1 µM, 940 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Summary AID for the MLPCN Project HTS for small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress
HTS for small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress
Assay data:8243 Active, 219165 Tested
Determination of inhibition of thapsigargin-initiated CHOP protein induction in ER stress signaling.
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