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Menin-MLL In Vitro Inhibitory Activity from US Patent US20240140953: "INHIBITORS OF MENIN-MLL INTERACTION"
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Determination of Binding Constants to Menin-MLL from US Patent US11919901: "Inhibitors of the menin-MLL interaction"
Assay data:253 Active, 249 Activity ≤ 1 nM, 253 Activity ≤ 1 µM, 253 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Competitive binding affinity to full length wild type MLL (unknown origin)
Assay data:5 Active, 1 Activity ≤ 1 µM, 7 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human Menin to MLL protein-protein interaction
Assay data:4 Active, 2 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
Inhibition of Menin to MLL (unknown origin) protein-protein interaction
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 4 Tested
Enzyme assay of inhibition against MLL1-WDR5 protein-protein interactions from US Patent US20230286948: "HALOALKYLPYRIDYL TRIAZOLE MLL1-WDR5 PROTEIN-PROTEIN INTERACTION INHIBITOR"
Assay data:21 Active, 10 Activity ≤ 1 µM, 56 Tested
Enzyme Assay of Inhibition Against MLL1-WDR5 Protein-Protein Interactions from US Patent US20230286925: "PHENYL TRIAZOLE MLL1-WDR5 PROTEIN-PROTEIN INTERACTION INHIBITOR"
Assay data:33 Active, 32 Activity ≤ 1 µM, 33 Tested
Selectivity interaction (Methyltransferase panel (Scintillation proximity assay (SPA))) EUB0000212b MLL
Assay data:1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (Methyltransferase panel) EUB0000196bCl MLL
Selectivity interaction (Methyltransferase panel (radioactive enzyme assay)) EUB0000216b MLL
Selectivity interaction (HMT panel) EUB0000194b MLL
Inhibition of MLL1 (unknown origin) using peptide substrate preincubated for 10 mins followed by substrate addition for 4 hrs by HTRF assay
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of MLL1-WDR5 (unknown origin) interaction using 10mer-Thr-FAM as substrate by fluorescence polarization based competitive binding assay
Inhibition of MLL1 (unknown origin) histone methyltransferase activity
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of human MLL1 at 10 uM by radioisotope-based filter binding assay
Inhibition of recombinant human his-tagged MLL1 (3745 to 3969residues) at 1 to 10 uM incubated for 60 mins in presence of [3H]-SAM by hotspot assay
Inhibition of N-terminal His-tagged MLL1 (3745 to 3969 residues) (unknown origin) expressed in Escherichia coli at 1 uM using 3H-SAM as a substrate relative to control
Inhibition of GST-tagged human MLL1 (1147 to 1203 residues) expressed in Escherichia coli BL21 cells incubated for 30 mins by fluorescence polarization assay
Assay data:4 Active, 29 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human recombinant N-terminal his-tagged MLL1 (3745 to 3969 residues) expressed in Escherichia coli at 50 uM by scintillation/filter plate assay relative to control
Inhibition of human recombinant N-terminal his-tagged MLL1 (3745 to 3969 residues) expressed in Escherichia coli at 10 uM by scintillation/filter plate assay
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