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Activation of recombinant human PP5 (16 to 499 residues) Escherichia coli BL21 (DE3) using pNPP incubated for 60 mins
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human full length PP5 expressed in Escherichia coli Rosetta gami2(DE3)pLysS at >1 x 10^6nM relative to control
Assay data:1 Tested
Activation of PP5 (unknown origin) assessed as fold increase in activity at > 100000 nM relative to control
Inhibition of PP5 (unknown origin) using [3H]-phosphohistone as substrate by liquid scintillation counting analysis
Assay data:2 Active, 2 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human PP5 using [3H]-phosphohistone as substrate
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of PP5 (unknown origin)
Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
Assay data:3 Tested
Fluorescence Polarization Assay from Article 10.1074/jbc.M113.519421: "The molecular chaperone Hsp70 activates protein phosphatase 5 (PP5) by binding the tetratricopeptide repeat (TPR) domain."
Assay data:8 Active, 6 Activity ≤ 1 µM, 9 Tested
Inhibition of PP5 (unknown origin) using pNPP as substrate at 200 uM after 5 mins by spectrophotometry
Inhibition of phosphatase activity of human PP5 using pNPP as a substrate after 10 mins by spectrophotometer analysis
Assay data:4 Tested
Inhibition of PP5 (unknown origin) using pNPP as substrate at pH 7 at 25 degC by spectrophotometric analysis
Late stage assay provider results from the probe development effort to identify inhibitors of PP1: fluorescence-based biochemical dose response assay to determine activity of inhibitors on dephosphorylation of OMFP by PP5, Set 2
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Late stage assay provider counterscreen for the probe development effort to identify inhibitors of PP1: radiolabel-based biochemical assay to determine activity of inhibitors on dephosphorylation of phosphohistone by PP5
Assay data:7 Tested
Late stage assay provider results from the probe development effort to identify inhibitors of PP1: fluorescence-based biochemical dose response assay to determine activity of inhibitors on dephosphorylation of OMFP by PP5, Set 1
Late stage assay provider counterscreen for the probe development effort to identify inhibitors of PP1: radiolabel-based biochemical dose response assay to determine activity of inhibitors on dephosphorylation of glycogen phosphorylase by PP5, Set 2
Assay data:1 Active, 5 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Late stage assay provider results from the probe development effort to identify inhibitors of PP1: fluorescence-based biochemical counterscreen assay to determine activity of inhibitors on dephosphorylation of OMFP by PP5
Assay data:2 Active, 36 Tested
Late stage assay provider counterscreen for the probe development effort to identify inhibitors of PP1: radiolabel-based biochemical dose response assay to determine activity of inhibitors on dephosphorylation of glycogen phosphorylase by PP5
Assay data:3 Active, 5 Tested
Late stage assay provider results from the probe development effort to identify inhibitors of PP5: fluorescence-based biochemical dose response assay to determine activity of inhibitors on dephosphorylation of OMFP by PP5 (Round 5) (1uM low dose)
Assay data:8 Tested
Late stage assay provider counterscreen for the probe development effort to identify inhibitors of PP5: radiolabel-based biochemical dose response assay to determine activity of inhibitors on dephosphorylation of phosphohistone by PP2A (Round 5)
Late stage assay provider counterscreen for the probe development effort to identify inhibitors of PP5: radiolabel-based biochemical assay to determine activity of inhibitors on dephosphorylation of phosphohistone by PP2A (Round 5)
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