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Assay of Inhibitory Activity of Compounds of the Present Invention Against Wee-1 Kinase from US Patent US20240182482: "FUSED CYCLIC COMPOUND AS WEE-1 INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF"
Assay data:13 Active, 13 Activity ≤ 1 µM, 13 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
CDK1/CyclinB Kinase Inhibitory Activity Assay from US Patent US20240166635: "AMINOHETEROARYL KINASE INHIBITORS"
Assay data:166 Active, 167 Activity ≤ 1 µM, 167 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
In-Vitro Assay from US Patent US20240158369: "PYRIMIDINE COMPOUND AS WEE-1 INHIBITOR"
Assay data:146 Active, 157 Activity ≤ 1 µM, 157 Tested
CDK Inhibition In Vitro Assay from US Patent US20240150369: "CYCLIN-DEPENDENT KINASE INHIBITING COMPOUNDS FOR THE TREATMENT OF MEDICAL DISORDERS"
Assay data:31 Active, 8 Activity ≤ 1 nM, 31 Activity ≤ 1 µM, 31 Tested
Activity Inhibition Assay on CDK Family Kinases from US Patent US20240109898: "SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE-7-AMINE DERIVATIVES, COMPOSITIONS AND PHARMACEUTICAL USES THEREOF"
Assay data:84 Active, 83 Activity ≤ 1 µM, 84 Tested
CDK1/Cyclin B1 ADP-Glo Kinase Assay from US Patent US20240092761: "QUINAZOLINE COMPOUNDS AND METHODS OF USE"
Assay data:83 Active, 59 Activity ≤ 1 µM, 122 Tested
CDK1/Cyclin B1 ADP-Glo Kinase Assay from US Patent US20240034731: "AZA-QUINAZOLINE COMPOUNDS AND METHODS OF USE"
Assay data:75 Active, 1 Activity ≤ 1 nM, 52 Activity ≤ 1 µM, 99 Tested
Inhibition of WEE1 (unknown origin) at 10 uM by biochemical hotspot kinase assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of CDK1/cyclin B (unknown origin) at 10 uM by biochemical hotspot kinase assay
Inhibition of C-terminal His6 tagged human full length CDK1/N-terminal GST-tagged human full length Cyclin B expressed in baculovirus infected Sf21 cells using 5-FAM-QSPKKG-CONH2 as substrate at 10 uM incubated for 60 mins in presence of ATP relative to control
Inhibition of C-terminal His6 tagged human full length CDK1/N-terminal GST-tagged human full length Cyclin B expressed in baculovirus infected Sf21 cells using 5-FAM-QSPKKG-CONH2 as substrate incubated for 60 mins in presence of ATP
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of WEE1 in human U2OS cells incubated for 1 hr by mesoscale discovery assay
Assay data:42 Active, 36 Activity ≤ 1 µM, 42 Tested
Inhibition of human full length GST-tagged WEE1 expressed in insect cells incubated for 15 mins followed by ATP addition by ADP Glo luminescent assay
Assay data:49 Active, 47 Activity ≤ 1 µM, 49 Tested
Inhibition of Wee1 in human MV4-11 cells assessed as reduction in phosphorylation of CDK1-Y15 incubated for 24 hrs by Western blot analysis
Inhibition of recombinant human Wee1 (214 to end residues) incubated for 1 hr in presence of tracer 178 by fluorescence based assay
Assay data:40 Active, 39 Activity ≤ 1 µM, 40 Tested
Inhibition of CDK1/Cyclin B (unknown origin) in presence of ATP by scintillation counter analysis
Inhibition of CDK1/Cyclin B (unknown origin) at 1 uM incubated for 30 to 60 mins presence of dithiothreitol by Cheng-Prusoff equation analysis relative to control
Assay data:11 Tested
Inhibition of CDK1/Cyclin B (unknown origin) assessed as inhibition constant incubated for 30 to 60 mins presence of dithiothreitol by Cheng-Prusoff equation analysis
Assay data:10 Active, 10 Activity ≤ 1 µM, 10 Tested
Inhibition of CDK1/Cyclin B (unknown origin) assessed as inhibition constant
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Inhibition of cdk1/Cyclin B (unknown origin)
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