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Displacement of BODIPY-GTP from nucleotide binding site of wild-type GST-tagged Rab2 GTPase (unknown origin) at 100 nL after 2 hrs by flow cytometry
Assay data:1 Tested
SummaryRelated BioAssays by Target
Displacement of BODIPY-GTP from nucleotide binding site of wild-type GST-tagged Rab2 GTPase (unknown origin) after 2 hrs by flow cytometry
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Additional SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab2 wildtype
Assay data:42 Tested
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab2 wildtype
Assay data:3 Activity ≤ 1 µM, 92 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Oxadiazole SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab2 wildtype
Assay data:5 Activity ≤ 1 µM, 51 Tested
Activator binding kinetics on Ras and Ras-related GTPases, specifically Rab2_wt
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab2 wildtype
Assay data:23 Active, 9 Activity ≤ 1 µM, 1270 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab2 wildtype
Assay data:365 Active, 194656 Tested
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