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Inhibition of Purinergic P2X at 10.0 M in the Eurofins Panlabs Safety Screen
Assay data:1 Tested
SummaryRelated BioAssays by Target
Antagonist activity at rat P2X7 receptor
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Antagonist activity at mouse P2X7 receptor
Assay data:4 Active, 3 Activity ≤ 1 µM, 4 Tested
Antagonist activity at human P2X7 receptor
Assay data:12 Active, 11 Activity ≤ 1 µM, 12 Tested
Antagonist activity at P2X7 receptor in human THP-1 cells assessed as inhibition of ATP-induced NLRP3 inflammasome activation at 0.1 to 2.5 uM pretreated with LPS for 3 hrs followed by incubation with compound for 40 mins followed by treatment with ATP for 1 hr by western blot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Antagonist activity at P2X7 receptor in human THP-1 cells assessed as inhibition of Bz-ATP-evoked channel current at 2 uM by whole-cell patch clamp analysis
SummaryPubMed CitationRelated BioAssays by Target
Antagonist activity at P2X7 receptor in human THP-1 cells assessed as inhibition of ATP-induced IL-1beta secretion pretreated with LPS for 3 hrs followed by incubation with compound for 40 mins followed by treatment with ATP for 1 hr by ELISA
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Antagonist activity at mouse P2X7 receptor expressed in HEK293 cells assessed as inhibition of ATP-induced receptor pore formation by propidium iodide dye uptake based fluorescence analysis
Assay data:19 Active, 17 Activity ≤ 1 µM, 19 Tested
Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of ATP-induced receptor pore formation by propidium iodide dye uptake based fluorescence analysis
Assay data:14 Active, 14 Activity ≤ 1 µM, 14 Tested
Antagonist activity at mouse P2X7 receptor expressed in HEK293 cells assessed as inhibition of ATP-induced receptor pore formation at 200 nM by propidium iodide dye uptake based fluorescence analysis
Assay data:32 Tested
Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of ATP-induced receptor pore formation at 200 nM by propidium iodide dye uptake based fluorescence analysis
Antagonist activity at mouse P2X7 receptor expressed in HEK293 cells assessed as inhibition of ATP-induced receptor pore formation at 1 uM by propidium iodide dye uptake based fluorescence analysis
Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of ATP-induced receptor pore formation at 1 uM by propidium iodide dye uptake based fluorescence analysis
Antagonist activity at mouse P2X7 receptor expressed in HEK293 cells assessed as inhibition of ATP-induced receptor pore formation at 10 uM by propidium iodide dye uptake based fluorescence analysis
Assay data:12 Tested
Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of ATP-induced receptor pore formation at 10 uM by propidium iodide dye uptake based fluorescence analysis
Antagonist activity at human P2X7 receptor in human blood assessed as ATP induced IL-1 beta
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Antagonist activity at P2X7 in human THP-1 cells
Antagonist activity at P2X7 receptor in mouse Peritoneal macrophage cells assessed as ATP induced dye uptake at 10 uM relative to control
Assay data:8 Tested
Antagonist activity at P2X7 receptor in mouse Peritoneal macrophage cells assessed as reduction in ATP induced IL-1 beta release
Assay data:1 Active, 4 Tested
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