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Inhibition of Tau phosphorylation at Thr212 in human SH-SY5Y cells at 0.01 to 10 uM by Western blot analysis
Assay data:2 Tested
SummaryRelated BioAssays by Target
Inhibition of cellular tau (unknown origin) aggregation incubated for 2 hrs by FRET assay
Assay data:2 Active, 2 Tested
Inhibition of cellular tau (unknown origin) aggregation at 10 uM incubated for 2 hrs by FRET assay
Inhibition of tau (unknown origin) aggregation at 10 uM relative to control
Assay data:1 Tested
Inhibition of tau phosphorylation (unknown origin)
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of Tau in human Huh-7 cells at 40 uM relative to control
Assay data:3 Tested
Inhibition of okadaic-acid induced tau hyperphosphorylation at Ser202/Thr205 residues in human SH-SY5Y cells at 0.1 uM preincubated with compound for 24 hrs followed by okadaic acid addition and measured after 20 hrs by Western blot analysis
Assay data:1 Active, 1 Tested
Inhibition of tau (306 to 336 residue) (unknown origin) aggregation at 50 uM incubated overnight by ThT fluorometric assay relative to control
Inhibition of tau (unknown origin) aggregation expressed in Escherichia coli BL21 (DE3)
Assay data:10 Active, 18 Tested
Inhibition of tau (unknown origin) aggregation expressed in Escherichia coli BL21 (DE3) at 10 uM relative to control
Assay data:8 Tested
Induction of tau degradation in mouse N2a cells at 150 uM measured after 24 hrs by Western blot analysis relative to control
3H-THK5117 Competition Binding to Tau Fibrils In Vitro from US Patent US20240165276: "SELECTIVE LIGANDS FOR TAU AGGREGATES"
Assay data:26 Active, 1 Activity ≤ 1 nM, 27 Activity ≤ 1 µM, 27 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Confirmatory Assay (CONFA) from US Patent US20240158379: "NOVEL BENZOFURAN, BENZOTHIOPHENE, AND INDOLE ANALOGS THAT INHIBIT THE FORMATION OF TAU OLIGOMERS AND THEIR METHOD OF USE"
Assay data:10 Active, 1 Activity ≤ 1 µM, 16 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
AlphaLisa Assay (ALA) from US Patent US20240158379: "NOVEL BENZOFURAN, BENZOTHIOPHENE, AND INDOLE ANALOGS THAT INHIBIT THE FORMATION OF TAU OLIGOMERS AND THEIR METHOD OF USE"
Assay data:18 Active, 2 Activity ≤ 1 µM, 22 Tested
Confirmatory Assay (CONFA) from US Patent US20240158357: "NOVEL QUINAZOLINONES THAT INHIBIT THE FORMATION OF TAU OLIGOMERS AND THEIR METHOD OF USE"
Assay data:7 Active, 13 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Target
AlphaLisa Assay (ALA) from US Patent US20240158357: "NOVEL QUINAZOLINONES THAT INHIBIT THE FORMATION OF TAU OLIGOMERS AND THEIR METHOD OF USE"
Assay data:13 Active, 17 Tested
Displacement of [11C]PBB3 in human brain tau incubated for 30 mins by radioligand binding assay relative to control
Assay data:22 Tested
SummaryPubMed CitationRelated BioAssays by Target
Displacement of [11C]PBB3 in human brain tau incubated for 30 mins by radioligand binding assay
Assay data:18 Active, 1 Activity ≤ 1 nM, 20 Activity ≤ 1 µM, 22 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of tau 4R1N phosphorylation (unknown origin) at S396 residue transfected in human U2OS cells coexpressing GFP-tagged beta catenin incubated overnight by high content imaging assay
Assay data:12 Active, 12 Activity ≤ 1 µM, 12 Tested
Assay data:68 Active, 1 Activity ≤ 1 nM, 60 Activity ≤ 1 µM, 68 Tested
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