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Binding affinity to NTA chip immobilised recombinant SARS-CoV-2 Delta spike protein RBD at 50 uM measured for 500 secs by SPR analysis
Assay data:3 Tested
SummaryRelated BioAssays by Target
Inhibition of SARS-COV-2 S1 protein/human ACE2 receptor interaction at 20 uM by co-immunoprecipitation assay
Binding affinity to C-terminal 6His-tagged SARS-COV-2 recombinant S protein (Val16 to Arg685 residues) expressed in mammalian expression system assessed as dissociation constant by SPR analysis
Assay data:1 Active, 1 Tested
Inhibition of human ACE2 catalytic domain (Ser19 to Asp615 residues) binding to poly-his tagged SARS-CoV-2 Wuhan Spike protein RBD assessed as fold increase in ACE2 concentration at 0.5 mM by MST analysis
Assay data:2 Tested
Inhibition of human ACE2 catalytic domain (Ser19 to Asp615 residues) binding to poly-his tagged SARS-CoV-2 Wuhan Spike protein (1 to 1208 residues) at 0.5 mM by MST analysis
Assay data:1 Active, 2 Tested
Binding affinity to Poly-his tagged SARS-CoV-2 Wuhan Spike protein RBD assessed as dissociation constant incubated for 15 mins by MST analysis
Binding affinity to Poly-his tagged SARS-CoV-2 Wuhan Spike protein (1 to 1208 residues) assessed as dissociation constant incubated for 15 mins by MST analysis
Binding affinity to C-terminal 6His-tagged SARS-CoV-2 Wuhan Spike protein RBD (Arg319 to Phe541 residues) expressed in baculovirus insect cells assessed as destabilization at lower concentrations incubated at 21 degreeC for 10 mins by thermofluor assay
Assay data:2 Active, 2 Tested
Binding affinity to C-terminal 6His-tagged SARS-CoV-2 Wuhan Spike protein RBD (Arg319 to Phe541 residues) expressed in baculovirus insect cells assessed as destabilization by measuring curve shift towards lower temperature at 100 uM incubated at 21 degreeC for 10 mins by thermofluor assay
Assay data:6 Active, 7 Tested
Inhibition of SARS-CoV-2 spike protein RBD- human ACE2 interaction pretreated with SARS-CoV-2 spike RBD for 2 hrs followed by ACE2 addition and measured after 2 hrs by TMP based ELISA analysis
Inhibition of SARS-CoV-2 spike protein RBD- human ACE2 interaction at 10 uM pretreated with SARS-CoV-2 spike RBD for 2 hrs followed by ACE2 addition and measured after 2 hrs by TMP based ELISA analysis relative to control
Assay data:14 Tested
Inhibition of d2-labelled SARS-CoV-2 spike protein RBD-terbium labelled SNAP tagged human ACE2 interaction transfected in HEK293 cells at 100 uM preincubated with cells for 1 hrs followed by RBD-d2 addition and measured after 2 hrs by TR-FRET assay relative to control
Assay data:7 Tested
Inhibition of SARS-CoV-2 spike protein RBD- human ACE2 interaction incubated for 1 hr by colorimetric ELISA assay
Assay data:1 Tested
Inhibition of SARS-CoV-2 spike protein RBD- human ACE2 interaction at 30 uM incubated for 1 hr by colorimetric ELISA assay relative to control
Assay data:6 Tested
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Binding affinity to his tagged recombinant SARS-CoV-2 B1.617.2 (Delta) spike protein assessed as dissociation constant measured after 240 secs by biolayer interferometry assay
Binding affinity to biotinylated recombinant SARS-CoV-2 spike protein RBD assessed as dissociation constant measured after 240 secs by biolayer interferometry assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of Compounds on Viral Replication from US Patent US20240166680: "NUCLEOSIDE ANALOG AND USE THEREOF"
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Binding affinity to SARS-COV-2 spike protein S2 subunit assessed as inhibition S2 subunit HR1 assessed as dissociation constant
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity of SARS-COV2 S-RBD by BLI assay
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
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