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LSD1 Enzyme Activity Assay from US Patent US20240216357: "POLYCYCLIC COMPOUND AND APPLICATION THEREOF"
Assay data:265 Active, 69 Activity ≤ 1 nM, 263 Activity ≤ 1 µM, 265 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
LSD1 Inhibition of the Crystal Form A of the Compound III from US Patent US12024494: "Salt of LSD1 inhibitor and a polymorph thereof"
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Evaluation of Enzyme Activity from US Patent US20240199571: "THIOPHENE COMPOUND AND APPLICATION THEREOF"
Assay data:88 Active, 88 Activity ≤ 1 µM, 88 Tested
Enzymatic Activity Assay from US Patent US11944614: "Imidazo[4,5-c]pyridine compounds as LSD-1 inhibitors"
Assay data:32 Active, 33 Activity ≤ 1 µM, 33 Tested
Inhibition of human LSD1 in human LSD1 knockout BGC-823 cells assessed as effect on H3K4me3 methylation at 5 to 20 uM incubated for 5 days by Western blot anlaysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human LSD1 in human LSD1 knockout BGC-823 cells assessed as effect on H3K4me2 methylation at 5 to 20 uM incubated for 5 days by Western blot anlaysis
Inhibition of human LSD1 in human LSD1 knockout BGC-823 cells assessed as effect on H3K4me1 methylation at 5 to 20 uM incubated for 5 days by Western blot anlaysis
Inhibition of human LSD1 in human BGC-823 cells assessed as inhibition of H3K4me3 demethylation at 5 to 20 uM incubated for 5 days by Western blot anlaysis
Inhibition of human LSD1 in human BGC-823 cells assessed as inhibition of H3K4me2 demethylation at 5 to 20 uM incubated for 5 days by Western blot anlaysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human LSD1 in human BGC-823 cells assessed as inhibition of H3K4me1 demethylation at 5 to 20 uM incubated for 5 days by Western blot anlaysis
Binding affinity to LSD1 (unknown origin) assessed as increase in thermostability incubated for 6 hrs by CESTA analysis
Assay data:2 Active, 2 Tested
Inhibition of recombinant LSD1 (unknown origin) expressed in Escherichia coli BL21 (DE3) using H3K4me2 peptide as substrate incubated for 30 mins by fluorescence based microplate reader assay
Assay data:41 Active, 11 Activity ≤ 1 µM, 48 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of recombinant LSD1 (unknown origin) expressed in Escherichia coli BL21 (DE3) using H3K4me2 peptide as substrate at 10 uM incubated for 30 mins by fluorescence based microplate reader assay
Assay data:48 Tested
Inhibition of LSD1 in human IMR-32 cells assessed as increase in H3K4me2 level at 0.333 uM measured for 72 hrs by DAPI staining based analysis relative to control
Assay data:2 Tested
Inhibition of LSD1 in human CHP-134 cells assessed as increase in H3K4me2 level at 0.037 uM measured for 72 hrs by DAPI staining based analysis relative to control
Inhibition of LSD1 in human CHP-134 cells assessed as increase in H3K4me2 level at 0.111 uM measured for 72 hrs by DAPI staining based analysis relative to control
Mixed inhibition of human recombinant LSD1 upto 50 uM in presence of H2O2 by HRP-coupled assay
Inhibition of human recombinant LSD1 assessed as inhibition constant by HRP-coupled assay
Inhibition of N-terminal his-tagged human recombinant LSD1 using 10-acetyl-3,7-dihydroxyphenoxazine as substrate measured for 30 mins by multiplate reader analysis
Assay data:8 Active, 4 Activity ≤ 1 µM, 43 Tested
Inhibition of N-terminal his-tagged human recombinant LSD1 at 10 uM using 10-acetyl-3,7-dihydroxyphenoxazine as substrate measured for 30 mins by multiplate reader analysis relative to control
Assay data:44 Tested
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