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Assay for Inhibition of Compounds Provided in the Present Application on CYP Enzymes from US Patent US20240226107: "UBIQUITIN-SPECIFIC PROTEASE 1 (USP1) INHIBITOR"
Assay data:1 Active, 2 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Target
The Inhibitory Effect of the Compound on the Activity of Human Liver Microsomal Cytochrome P450 Isoenzymes (CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4) from US Patent US12030897: "Pyrrolo[2,1-f][1,2,4]triazine derivatives serving as selective HER2 inhibitors and application thereof"
Assay data:1 Tested
SummaryRelated BioAssays by DepositorRelated BioAssays by Target
CYP Enzyme Single Point Inhibition Assay from US Patent US20240208981: "NITROGEN-CONTAINING HETEROCYCLIC POLYCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF"
Assay data:1 Active, 4 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
CYP450 Enzyme Inhibition Assay from US Patent US20240208932: "ARYLAMINO DERIVATIVE ESTROGEN RECEPTOR MODULATOR AND USE THEREOF"
Assay data:4 Tested
SummaryRelated BioAssays by Target
Inhibition of Cytochrome P450 Oxidase from US Patent US20240158438: "POLYPEPTIDE COMPOUND AND APPLICATION THEREOF"
Assay data:2 Active, 31 Tested
CYP Enzyme Inhibition Assay from US Patent US11981669: "1,7-naphthyridine derivative and preparation method and use therefor"
Assay data:8 Tested
CYP Enzyme Inhibitory Activity IC50 Assay from US Patent US20240124479: "PYRIMIDINE CARBOXAMIDE COMPOUND AND USE THEREOF"
CYP inhibitio from US Patent US20240124434: "ATF6 INHIBITORS AND USES THEREOF"
Assay data:10 Active, 3 Activity ≤ 1 µM, 17 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibitory Activity Assay from US Patent US11952364: "TRK inhibitors useful as anticancer drugs"
Assay data:3 Active, 1 Activity ≤ 1 µM, 3 Tested
CYP1A2 Inhibition Assay from US Patent US11938127: "Methods and compositions relating to steroid hormone receptor-dependent proliferative disorders"
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate at 10 uM preincubated for 10 mins followed by NADPH addition and measured after 15 mins by LC-MS/MS analysis
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of CYP1A2 (unknown origin)
Assay data:3 Tested
Reversible inhibition of CYP1A2 in human liver microsomes assessed as residual activity at 5 uM using phenacetin as substrate preincubated for 30 mins followed by substrate addition measured after 20 mins by LC-MS/MS analysis relative to control
Inhibition of human CYP1A2
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of CYP1A2 in human liver microsomes using midazolam as substrate preincubated for 15 mins followed by NADPH addition and measured after 8 mins by LC/MS/MS analysis
Assay data:1 Active, 1 Tested
Induction of CYP1A2 in human hepatocytes
Inhibition of recombinant CYP1A1 (unknown origin) assessed as decrease in EROD activity using 7-ethoxyresorufin as substrate upto 100 uM incubated for 15 mins by resorufin dye based spectrofluorimetry
Assay data:6 Tested
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