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Antagonist activity at human pA2
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Antagonist activity at rat PA2 transfected in xenopus oocyte cell
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Antagonist activity at human pA2 by FLIPR assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Antagonist activity at pA2 (unknown origin)
Inhibition of recombinant human sPLA2-V
Assay data:7 Active, 2 Activity ≤ 1 µM, 7 Tested
Inhibition of human recombinant sPLA2-V at 1 uM
Inhibition of human group IIA phospholipase A2 incubated for 10 to 20 mins cells by radiometric assay
Inhibition of mouse group IIA phospholipase A2 incubated for 10 to 20 mins cells by radiometric assay
Inhibition of human group IIA phospholipase A2 preincubated with compound for 10 mins followed by enzyme addition and measured after 30 mins by PC/DOC assay
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Inhibition of human group IIA phospholipase A2 incubated for 30 mins by automatic plate reader analysis
Assay data:5 Active, 4 Activity ≤ 1 µM, 7 Tested
Inhibition of human group IIA phospholipase A2 incubated for 1 hrs by scintillation counter analysis
Inhibition of human PLA2G2A
Assay data:5 Active, 1 Activity ≤ 1 µM, 5 Tested
Inhibitory Activity Assay from Article 10.1111/cbdd.12307: "Discovery of novel secretory phospholipase A2 inhibitors using virtual screen."
Assay data:2 Active, 7 Tested
Fluorimetric Assay from Article 10.1016/j.bmc.2007.10.077: "Design of new potent and selective secretory phospholipase A2 inhibitors. Part 5: synthesis and biological activity of 1-alkyl-4-[4,5-dihydro-1,2,4-[4H]-oxadiazol-5-one-3-ylmethylbenz-4'-yl(oyl)] piperazines."
Assay data:14 Active, 4 Activity ≤ 1 µM, 21 Tested
Enzymatic Inhibition Assay from Article 10.1021/jm7010707: "Chemically induced dimerization of human nonpancreatic secretory phospholipase A2 by bis-indole derivatives."
Assay data:11 Active, 11 Activity ≤ 1 µM, 11 Tested
Inhibition of sPLA2 in atherosclerotic plaque from coronary artery disease patient
Inhibition of sPLA2 in human HepG2 cells
Inhibition of sPLA2 in human plasma at 25 uM using 1-Hexadecanoyl-2-(1-pyrenedecanoyl)-sn-glycero-3-phosphomethanol as substrate preincubated for 10 mins followed by substrate addition measured after 90 mins by fluorescence assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of sPLA2 in human plasma using 1-Hexadecanoyl-2-(1-pyrenedecanoyl)-sn-glycero-3-phosphomethanol as substrate preincubated for 10 mins followed by substrate addition measured after 90 mins by fluorescence assay
Assay data:9 Active, 4 Activity ≤ 1 nM, 9 Activity ≤ 1 µM, 11 Tested
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