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Competitive binding affinity to recombinant alpha-synuclein (unknown origin) assessed as inhibition constant incubated for 0.5 hrs by ThT-based fluorescence microplate reader analysis
Assay data:20 Active, 23 Activity ≤ 1 µM, 26 Tested
SummaryRelated BioAssays by Target
Inhibition of human alpha-synuclein aggregation expressed in Escherichia coli BL21 (DE3) at 400 uM measured after 36 hrs by thioflavin T fluorescence assay
Assay data:1 Tested
Inhibition of human alpha-synuclein aggregation expressed in Escherichia coli BL21 (DE3) at 10:1 compound to protein molar ratio measured after 36 hrs by thioflavin T fluorescence assay relative to control
Binding affinity to human alpha-synuclein expressed in Escherichia coli BL21 (DE3) at 100 uM incubated for 3 hrs by ETD Q-TOF ((+) HRESIMS) analysis
Assay data:1 Active, 8 Tested
Inhibition of alpha-synuclein (unknown origin) dimerization transfected in mouse Neuro2a cells at 10 uM incubated for 4 hrs by Protein-fragment complementation assay
Assay data:1 Active, 1 Tested
Inhibition of alpha-synuclein (unknown origin) dimerization transfected in PREP knockout HEK293 cells at 10 uM incubated for 4 hrs by Protein-fragment complementation assay
Inhibition of alpha-synuclein (unknown origin) dimerization transfected in PREP knockout HEK293 cells at 10 uM incubated for 4 hrs by luminescence based multimode plate reader method
Inhibition of alpha-synuclein (unknown origin) dimerization transfected in HEK293 cells at 10 uM incubated for 4 hrs by luminescence based multimode plate reader method
Inhibition of alpha-synuclein (unknown origin) dimerization transfected in mouse Neuro2a cells assessed as reduction in aggregation at 10 uM incubated for 4 hrs by split Gaussia luciferase-based assay relative to control
Assay data:34 Tested
Binding affinity to wildtype alpha-synuclein monomer (unknown origin) expressed in Escherichia coli BL21 (DE3) cells assessed as inhibition of beta-sheet formation by measuring negative ellipticity value at 218 nm wavelength at 30 uM measured after 72 hrs by circular dichroism spectroscopy analysis
Assay data:7 Tested
Binding affinity to wildtype alpha-synuclein monomer (unknown origin) expressed in Escherichia coli BL21 (DE3) cells assessed as stabilization of secondary structure by measuring negative ellipticity value at 200 nm wavelength at 30 uM measured immediately by circular dichroism spectroscopy analysis
Assay data:2 Tested
Binding affinity to wildtype alpha-synuclein monomer (unknown origin) expressed in Escherichia coli BL21 (DE3) cells assessed as stabilization of secondary structure by measuring negative ellipticity value at 204 nm wavelength at 30 uM measured immediately by circular dichroism spectroscopy analysis
Assay data:5 Tested
Inhibition of alpha-synuclein inclusion formation in human H4 cells transfected with pcDNA3.1/delta155 and pcDNA3.1/SNCAIP plasmid assessed as fold decrease in number of cells with decreased inclusions at 10 uM administered at 10 hrs and measured after 48 hrs by fluorescence based confocal microscopic analysis
Inhibition of alpha-synuclein inclusion formation in human H4 cells transfected with pcDNA3.1/delta155 and pcDNA3.1/SNCAIP plasmid assessed as decrease in number of loosely packed inclusions at 10 uM administered at 10 hrs and measured after 48 hrs by fluorescence based confocal microscopic analysis
Assay data:2 Active, 2 Tested
Inhibition of alpha-synuclein inclusion formation in human H4 cells transfected with pcDNA3.1/delta155 and pcDNA3.1/SNCAIP plasmid assessed as disappearance of compacted inclusion at 10 uM administered at 10 hrs and measured after 48 hrs by fluorescence based confocal microscopic analysis
Disaggregation of wildtype recombinant alpha-synuclein (unknown origin) mature fibers expressed in Escherichia coli BL21 (DE3) cells assessed as appearance of monomers in soluble protein by measuring higher ionic strength by MALDI-TOF MS analysis
Disaggregation of wildtype recombinant alpha-synuclein (unknown origin) mature fibers expressed in Escherichia coli BL21 (DE3) cells assessed as fold increase in total soluble proteins by SDS-PAGE based image-grey assay
Disaggregation of wildtype recombinant alpha-synuclein (unknown origin) mature fibers expressed in Escherichia coli BL21 (DE3) cells assessed as decrease in width of rod fibers in soluble proteins at 100 uM incubated for 48 hrs by AFM analysis
Disaggregation of wildtype recombinant alpha-synuclein (unknown origin) mature fibers expressed in Escherichia coli BL21 (DE3) cells assessed as decrease in average height of rod fibers in soluble proteins at 100 uM incubated for 48 hrs by AFM analysis
Disaggregation of wildtype recombinant alpha-synuclein (unknown origin) mature fibers expressed in Escherichia coli BL21 (DE3) cells assessed as appearance of small number of small spherical particles in soluble proteins at 100 uM incubated for 48 hrs by AFM analysis
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