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Agonist activity at FFA4 (unknown origin) expressed in CHO-K1 cells by BRET assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Invivo agonist activity at GPR120 in C57BL/6 mouse assessed as reduction in glucose AUC levels at 30 mg/kg,po and measured upto 120 mins by OGTT test
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Agonist activity at human GPR120 expressed in CHO cells assessed as intracellular phosphorylated ERK incubated for 16 to 18 hrs by AlphaScreen SureFire assay
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate at 10 uM incubated for 90 mins by TopCount NXT counter based analysis relative to control
Assay data:90 Tested
Agonist activity at N-terminal FLAG tagged human FFAR4 transfected in African green monkey COS-7 cells assessed as accumulation of inositol phosphate incubated for 90 mins by TopCount NXT counter based analysis
Assay data:31 Active, 9 Activity ≤ 1 µM, 90 Tested
Agonist activity at human GPR120 expressed in CHO-K1 cells by BRET assay
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as cAMP accumulation
Agonist activity at human GPR120 expressed in CHO-K1 cells by beta-arrestin assay
Agonist activity at human GPR120 expressed in CHO-K1 cells assessed as calcium accumulation
Agonist activity at human GPR120 expressed in HEK293 cells by beta-arrestin assay
Agonist activity at human GPR120 expressed in HEK293 cells assessed as calcium accumulation
Agonist activity at GPR120 (unknown origin)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
GPCR beta-arrestin recruitment assay with target: FFAR4 Assay Type: PRESTO-Tango Concentration: 0.0000004
Assay data:211 Tested
SummaryRelated BioAssays by Target
GPCR beta-arrestin recruitment assay with target: FFAR4 Assay Type: PRESTO-Tango Concentration: 0.000002
GPCR beta-arrestin recruitment assay with target: FFAR4 Assay Type: PRESTO-Tango Concentration: 0.00001
Assay data:437 Tested
Measurement of Activity of GPR120 Agonist (Cell-Based Assay) from US Patent US11261186: "Biaryl derivative as GPR120 agonist"
Assay data:547 Active, 361 Activity ≤ 1 µM, 587 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
GPR120 pERK AlphaScreen SureFire Assay from US Patent US10336684: "Phenyl-(aza)cycloalkyl carboxylic acid GPR120 modulators"
Assay data:50 Active, 18 Activity ≤ 1 µM, 53 Tested
GPR120 pERK assay from US Patent US9938222: "Cyclopropanecarboxylic acid GPR120 modulators"
Assay data:115 Active, 75 Activity ≤ 1 µM, 116 Tested
BRET assay from US Patent US10273230: "Substituted phenyl alkanoic acid compounds as GPR120 agonists and uses thereof"
Assay data:15 Active, 4 Activity ≤ 1 µM, 15 Tested
Beta arrestin 2 Interaction Assay (BRET assay) from US Patent US10227360: "Compounds for use as GPR120 agonists"
Assay data:41 Active, 30 Activity ≤ 1 µM, 49 Tested
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