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CDK9/CyclinT1 Kinase Inhibitory Activity Assay from US Patent US20240166635: "AMINOHETEROARYL KINASE INHIBITORS"
Assay data:143 Active, 156 Activity ≤ 1 µM, 156 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
CDK Inhibition In Vitro Assay from US Patent US20240150369: "CYCLIN-DEPENDENT KINASE INHIBITING COMPOUNDS FOR THE TREATMENT OF MEDICAL DISORDERS"
Assay data:31 Active, 8 Activity ≤ 1 nM, 31 Activity ≤ 1 µM, 31 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
In Vitro Enzymatic Inhibitory Activity Assay from US Patent US20240132489: "AROMATIC HETEROCYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION, AND USE THEREOF"
Assay data:55 Active, 55 Activity ≤ 1 µM, 55 Tested
Activity Inhibition Assay on CDK Family Kinases from US Patent US20240109898: "SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE-7-AMINE DERIVATIVES, COMPOSITIONS AND PHARMACEUTICAL USES THEREOF"
Assay data:84 Active, 83 Activity ≤ 1 µM, 84 Tested
Inhibition of C-terminal His6 tagged full length recombinant human CDK9/full length human Cyclin T1 expressed in baculovirus infected Sf21 cells using 5-FAM-ACSYSPTSPSYSPTSPSYSPTSPSKK as substrate at 10 uM incubated for 60 mins in presence of ATP relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of C-terminal His6 tagged full length recombinant human CDK9/full length human Cyclin T1 expressed in baculovirus infected Sf21 cells using 5-FAM-ACSYSPTSPSYSPTSPSYSPTSPSKK as substrate incubated for 60 mins in presence of ATP
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of CDK9/Cyclin T1 (unknown origin) assessed as inhibition of substrate peptide phosphorylation using MBP as peptide substrate incubated for 2 hrs in presence of ATP by Lance Ultra HTRF assay
Covalent inhibition of CDK9 (unknown origin) using histone H1 as substrate incubated for 10 mins in presence of [gamma-32P]ATP by radioactivity based kinase assay
Assay data:4 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of CDK9 (unknown origin)
Inhibition of CDK9/Cyclin T (unknown origin) using (YSPTSPS)3 peptide as substrate incubated for 30 mins in presence of gamma[33P]ATP by digital imaging analysis
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Inhibition of CDK9/cyclin T1 (unknown origin) using as PDKtide substrate incubated for 1 hr in presence of ATP by ADP-glo luminescent assay
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
Assay data:7 Active, 7 Activity ≤ 1 µM, 7 Tested
Inhibition of CDK9/cyclin T1 (unknown origin) at 1 uM incubated for 30 to 60 mins presence of dithiothreitol by Cheng-Prusoff equation analysis relative to control
Assay data:14 Tested
Inhibition of CDK9/cyclin T1 (unknown origin) assessed as inhibition constant incubated for 30 to 60 mins presence of dithiothreitol by Cheng-Prusoff equation analysis
Inhibition of CDK9/cyclin T1 (unknown origin) assessed as inhibition constant
Inhibition of CDK9/cyclin T (unknown origin) assessed as inhibition constant
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Protac activity at CRBN/CDK9 in human HCT-116 cells at 20 uM relative to control
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of CDK9/Cyclin-T1 (unknown origin) assessed as reduction in substrate peptide phosphorylation using DYRKtide peptide as substrate preincubated for 12 mins followed by ATP addition and measured for 45 mins by mobility shift assay
Assay data:19 Active, 19 Activity ≤ 1 µM, 22 Tested
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