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Inhibition of mTOR FKBP12(h) at 10.0 M in the Eurofins Kinase panel
Assay data:1 Tested
SummaryRelated BioAssays by Target
PROTAC activity at CRBN/PTPN2 in human Jurkat cells assessed as induction of PTPN2 degradation at 0.01 to 10 uM by Western blot analysis
Assay data:5 Active, 5 Tested
PROTAC activity at CRBN/ITK in Balc/c mouse Primary splenic cell assessed as maximum degradation at 0.32 to 5000 nM by immunoblotting analysis relative to control
PROTAC activity at CRBN/ITK in Balc/c mouse Primary splenic cell assessed as ITK degradation by immunoblotting analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
PROTAC activity at CRBN/ITK in human Jurkat cells assessed as downregulation of ITK protein by measuring fold change at 100 nM measured after 8 hrs
PROTAC activity at CRBN/ITK in human Jurkat cells assessed as downregulation of ITK degradation at 300 nM incubated for 8 hrs by tandem mass tag quantitative proteomic analysis
Assay data:1 Active, 1 Tested
PROTAC activity at CRBN/ITK in human Jurkat cells assessed as induction of ITK degradation at 0.01 to 10 uM measured after 16 hrs by Western blot analysis
PROTAC activity at CRBN/ITK in human Jurkat cells assessed as induction of ITK degradation at 100 nM measured after 2 hrs by Western blot analysis
PROTAC activity at CRBN/ITK in human Jurkat cells assessed as induction of ITK degradation at 100 nM pretreated with 5-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione for 1 hr followed by compound addition and measured after 2 hrs by Western blot analysis
PROTAC activity at CRBN/ITK in Jurkat cells assessed as induction of ITK degradation at 100 nM pretreated with GNE-9822 for 1 hr followed by compound addition and measured after 2 hrs by Western blot analysis
PROTAC activity at CRBN/ITK in human Jurkat cells assessed as induction of ITK degradation at 100 nM pretreated with MLN4924 for 1 hr followed by compound addition and measured after 2 hrs by Western blot analysis
PROTAC activity at CRBN/ITK in human Jurkat cells assessed as induction of ITK degradation at 100 nM pretreated with proteosome inhibitor carfilzomib for 1 hr followed by compound addition and measured after 2 hrs by Western blot analysis
PROTAC activity at CRBN/ITK in human MOLT-4 cells assessed as induction of ITK degradation
PROTAC activity at CRBN/ITK in human Jurkat cells assessed as downregulation of ITK protein at 100 nM preincubated with cells for 12 hrs followed by compound washout measured after 24 hrs
PROTAC activity at CRBN/ITK in human Jurkat cells assessed as reduction in ITK protein at 100 nM measured within 4 hrs
PROTAC activity at CRBN/ITK in human Jurkat cells assessed as residual activity at 10 uM incubated for 16 hrs relative to control
PROTAC activity at CRBN/ITK in human Jurkat cells assessed as maximum degradation at 0.01 to 10 uM by Western blot analysis relative to control
Assay data:20 Tested
PROTAC activity at CRBN/ITK in human Jurkat cells assessed as induction of ITK degradation by Western blot analysis
Assay data:19 Active, 19 Activity ≤ 1 µM, 20 Tested
Protac activity at CRBN/BRD4 in human MV4-11 cells assessed as degradation of BRD4 at 0.0001 to 1 uM incubated for 24 hrs
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