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BRM ATPase Inhibition Assay from US Patent US11958846: "Urea compounds and compositions as SMARCA2/BRM ATPase inhibitors"
Assay data:8 Active, 8 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
BRG1 ATPase Inhibition Activity from US Patent US11958846: "Urea compounds and compositions as SMARCA2/BRM ATPase inhibitors"
Luciferase reporter assay: SMARCA4 transcriptional activity in a SMARCA2-mutant cell line
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Luciferase reporter assay: SMARCA2 transcriptional activity in a SMARCA4-mutant cell line
Measurement of the ATPase catalytic activity using the ADP-Glo detection (SMARCA4)
Measurement of the ATPase catalytic activity using the ADP-Glo detection (SMARCA2)
Binding affinity to human partial length SMARCA4 (A1448 to S1575 residues) expressed in bacterial expression system by BROMOscan assay
Assay data:4 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to human partial length SMARCA2 (S1377 to Q1486 residues) expressed in bacterial expression system by BROMOscan assay
Binding affinity to BRG1 bromodomain (unknown origin) incubated for 60 mins by TR-FRET assay
Assay data:1 Tested
Displacement of biotinylated JQ1 from BRG1 bromodomain (unknown origin) incubated for 20 mins by AlphaLISA assay
Binding affinity to SMARCA2A (unknown origin) assessed as change in melting temperature at 200 uM incubated for 30 to 60 mins by SYPRO orange dye based thermal shift assay
Assay data:2 Tested
Inhibition of SMARCA4 BD (unknown origin)
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of SMARCA2 BD (unknown origin)
SMARCA4 Bromodomain Binary and Ternary Binding Assay from US Patent US20240018158: "BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE"
SMARCA2 Bromodomain Binary and Ternary Binding Assay from US Patent US20240018158: "BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE"
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Selectivity interaction (Bromodomain panel (DSF assay)) EUB0000201c SMARCA4
SummaryRelated BioAssays by Target
Selectivity interaction (Bromodomain panel (DSF assay)) EUB0000199c SMARCA4
Selectivity interaction (Bromodomain panel (DSF assay)) EUB0000199c SMARCA2
Affinity Biochemical interaction (Isothermal titration calorimetry (ITC)) EUB0000199c SMARCA2
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Affinity On-target Cellular interaction (FRAP assay in U2OS cells full-length SMARCA4 protein) EUB0000199c SMARCA4
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