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Enzymatic IC50 Assays from US Patent US11584755: "Dihydrothieno[3,2-b]pyridine compounds"
Assay data:163 Active, 115 Activity ≤ 1 µM, 165 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Enzymatic Assay from US Patent US11253521: "3-hydroxy-quinazoline-2,4-dione derivatives and their use as nuclease modulators"
Assay data:71 Active, 67 Activity ≤ 1 µM, 71 Tested
Steady-State Kinetics from Article 10.1038/nchembio.2148: "Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site."
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding Assay from US Patent US9745328: "Flap modulators"
Assay data:801 Active, 94 Activity ≤ 1 nM, 763 Activity ≤ 1 µM, 885 Tested
Binding Assay from US Patent US9732093: "FLAP modulators"
Assay data:331 Active, 6 Activity ≤ 1 nM, 315 Activity ≤ 1 µM, 353 Tested
Inhibition of nuclease activity of EXO1 (unknown origin) up to 125 uM using DNA substrate
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of nuclease activity of FEN1 (unknown origin) up to 125 uM using DNA substrate
Inhibition of FEN1 (unknown origin)
Assay data:22 Active, 10 Activity ≤ 1 µM, 38 Tested
Assay data:41 Tested
SummaryPubMed CitationRelated BioAssays by Target
qHTS Assay for the Inhibitors of FEN1: Confirmatory Assay for Cherry-picked Compounds
Assay data:696 Active, 7 Activity ≤ 1 µM, 882 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1).
Assay data:1368 Active, 233 Activity ≤ 1 µM, 391275 Tested
qHTS Validation Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1)
Assay data:56 Active, 13 Activity ≤ 1 µM, 1280 Tested
Probe Development Summary for Inhibitors of Human Flap endonuclease 1 (FEN1)
SummaryRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Inhibitory concentration against the xeroderma pigmentosum G
Assay data:28 Active, 22 Activity ≤ 1 nM, 28 Activity ≤ 1 µM, 28 Tested
Inhibitory concentration against the Flap endonuclease-1
Assay data:28 Active, 27 Activity ≤ 1 nM, 28 Activity ≤ 1 µM, 28 Tested
Concentration required for 50% inhibition of Xeroderma pigmentosum G
Assay data:19 Active, 4 Activity ≤ 1 µM, 36 Tested
Concentration required for 50% inhibition of Flap endonuclease-1
Assay data:17 Active, 5 Activity ≤ 1 µM, 36 Tested
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