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In Vitro Assay from US Patent US20240101531: "PYRIDINAMINE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS"
Assay data:373 Active, 166 Activity ≤ 1 µM, 419 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Potency index, ratio of retigabine EC50 to test compound EC50 for agonist activity at rat KCNQ2/3 channel expressed in CHO cells by patch clamp method
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Potency index, ratio of retigabine EC50 to test compound EC50 for agonist activity at rat KCNQ2 channel expressed in CHO cells by patch clamp method
Agonist activity at rat KCNQ2/3 channel expressed in CHO cells by patch clamp method
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at rat KCNQ2 channel expressed in CHO cells by patch clamp method
Agonist activity at rat KCNQ2/3 channel expressed in CHO cells assessed as amplitude change of outward current at 10 uM by patch clamp method
Agonist activity at rat KCNQ2/3 channel expressed in CHO cells assessed as shift of half voltage of maximal activation at 10 uM by patch clamp method
Agonist activity at rat KCNQ2/3 channel expressed in CHO cells assessed as amplitude change of outward current at 0.1 uM by patch clamp method
Agonist activity at rat KCNQ2/3 channel expressed in CHO cells assessed as shift of half voltage of maximal activation at 0.1 uM by patch clamp method
Agonist activity at rat KCNQ2 channel expressed in CHO cells assessed as amplitude change of outward current at 0.1 uM by patch clamp method
Agonist activity at rat KCNQ2 channel expressed in CHO cells assessed as shift of half voltage of maximal activation at 0.1 uM by patch clamp method
Agonist activity at rat Kv7.2 channel expressed in CHO cells assessed as amplitude change of outward current at 10 uM by whole cell patch clamp based electrophysiological method
Assay data:33 Tested
Agonist activity at rat Kv7.2 channel expressed in CHO cells assessed as shift of half voltage of maximal activation at 10 uM by whole cell patch clamp based electrophysiological method
Assay data:32 Tested
Potency index, ratio of retigabine EC50 to test compound EC50 for anticonvulsant activity in Kv7.2/Kv7.3 (unknown origin) channel expressed in CHO cells
Activation of Kv7.2/Kv7.3 channel (unknown origin) expressed in CHO cells assessed as maximum current density measured after 24 hrs by whole cell patch clamp based electrophysiological method
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Activation of Kv7.2/Kv7.3 channel (unknown origin) expressed in CHO cells assessed as fold change in maximum current density measured after 24 hrs by whole cell patch clamp based electrophysiological method relative to control
Assay data:3 Tested
Activation of Kv7.2/Kv7.3 channel (unknown origin) expressed in CHO cells at + 80 mV assessed as leftward shift change in half activation potential measured after 24 hrs by whole cell patch clamp based electrophysiological method
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
Activation of Kv7.2/Kv7.3 channel (unknown origin) expressed in CHO cells at -120 mV measured after 24 hrs by whole cell patch clamp based electrophysiological method
Activation of Kv7.2/Kv7.3 channel (unknown origin) expressed in CHO cells at -80 mV measured after 24 hrs by whole cell patch clamp based electrophysiological method
Assay data:3 Active, 3 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Activation of Kv7.2/Kv7.3 channel (unknown origin) expressed in CHO cells assessed as leftward shift change in half activation potential at 1 uM measured after 24 hrs by whole cell patch clamp based electrophysiological method
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