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Purinergic P2Y Eurofins Panlabs panel
Assay data:1 Tested
SummaryRelated BioAssays by Target
Antagonist activity at human P2Y12 assessed as inhibition constant
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Antagonist activity at human P2Y12
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Displacement of [3H]-2-MeS-ADP from human P2Y12 assessed as inhibition constant incubated for 30 mins
Antagonist activity at human P2Y12 by aggregation assay
Assay data:3 Active, 2 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
Antagonist activity at P2Y12 (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Antagonist activity at P2Y12 receptor in human blood platelets assessed as inhibition of VASP phosphorylation by measuring platelet reactivity index at 10 uM by ELISA (Rvb = 97%)
Assay data:4 Tested
SummaryPubMed CitationRelated BioAssays by Target
Antagonist activity at P2Y12 receptor in human blood platelets assessed as inhibition of ADP-induced platelet aggregation compound preincubated with blood for 5 mins prior to ADP addition by electrode aggregometry assay
Assay data:2 Active, 3 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Antagonist activity at P2Y12 receptor in human blood platelets assessed as inhibition of ADP-induced platelet aggregation at 0.1 uM compound preincubated with blood for 5 mins prior to ADP addition by electrode aggregometry assay
Assay data:3 Tested
Antagonist activity at P2Y12 receptor in human blood platelets assessed as inhibition of ADP-induced platelet aggregation at 1 uM compound preincubated with blood for 5 mins prior to ADP addition by electrode aggregometry assay
Antagonist activity at P2Y12 receptor in human blood platelets assessed as inhibition of ADP-induced platelet aggregation at 10 uM compound preincubated with blood for 5 mins prior to ADP addition by electrode aggregometry assay
Antagonist activity at P2Y12R (unknown origin) expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 15 mins in presence of IBMX by chromatography
Inhibition of human P2Y12
Activation of human P2Y12R
Inhibition of P2Y12 receptor in human platelet assessed as reduction in ADP-induced VASP phosphorylation by flow cytometry
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Displacement of [3H]2MeSADP from human P2Y12 preincubated for 5 mins followed by [3H]2MeSADP addition and measured after 15 mins by scintillation counting method
Binding affinity to human P2Y12 expressed in astrocytoma cells
Inhibition of 2-MeS-ADP induced P2Y12 (unknown origin) signalling expressed in CHO cells membrane incubated for 45 mins by 35S-GTPgammaS assay
Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
Displacement of 2-MeS[3H]-ADP from P2Y12 (unknown origin) expressed in HEK293 cells preincubated for 5 mins followed by 2-MeS[3H]-ADP addition and measured after 30 mins by Topcount beta counter analysis
Assay data:1 Active, 1 Tested
Displacement of tritium-labeled 2MeSADP from human P2Y12 expressed in CHO cells measured after 2 hrs by scintillation counting method
Assay data:11 Active, 6 Activity ≤ 1 nM, 11 Activity ≤ 1 µM, 11 Tested
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