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Detecting Inhibition of cAMP Production from US Patent US11912693: "Compounds for modulating S1P1 activity and methods of using the same"
Assay data:260 Active, 633 Activity ≤ 1 µM, 633 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Fluorescence Detection (FLIPR) Assay from US Patent US11584726: "Amino alcohol derivative, pharmaceutical composition and application thereof"
Assay data:2 Active, 2 Activity ≤ 1 µM, 3 Tested
Binding affinity to S1PR5 (unknown origin) by SPR assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Displacement of [32P]S1P from human recombinant S1PR5 incubated for 60 mins by competitive binding assay based scintillation counter
Assay data:1 Active, 8 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to S1PR5 (unknown origin) assessed as dissociation constant by surface plasmon resonance analysis
Assay data:8 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Competition Binding Assay from US Patent US11034691: "Sphinogosine-1 -phosphate receptor modulators for treatment of cardiopulmonary disorders"
Assay data:355 Active, 260 Activity ≤ 1 µM, 366 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
In Vitro Functional Activity (Agonism) on Human S1P5 Receptors from US Patent US10807991: "Spiro-cyclic amine derivatives as S1P modulators"
Assay data:42 Active, 42 Activity ≤ 1 µM, 42 Tested
Evaluation of S1P5 Receptor Agonist Activities from US Patent US10730830: "Tetrahydronaphthalene derivative"
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Measurement of the Inhibitory Action of the Compound of the Present Invention on Binding of [33P]-S1P to S1P5 (EDG-8) from US Patent US10730830: "Tetrahydronaphthalene derivative"
Assay data:24 Active, 18 Activity ≤ 1 µM, 24 Tested
In Vitro Binding Assay from US Patent US10676467: "Compositions for binding sphingosine-1-phosphate receptor 1 (S1P1), imaging of S1P1, and methods of use thereof"
Assay data:55 Active, 1 Activity ≤ 1 nM, 58 Activity ≤ 1 µM, 58 Tested
TBD from US Patent US10323029: "Sphinogosine-1-phosphate receptor modulators for treatment of cardiopulmonary disorders"
Assay data:354 Active, 260 Activity ≤ 1 µM, 365 Tested
[32P] S1P Binding Assay from Article 10.1016/j.bmc.2004.10.008: "Asymmetric synthesis and biological evaluation of the enantiomeric isomers of the immunosuppressive FTY720-phosphate."
Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
Ligand-Induced Uptake of [35S]-GTP-gamma-S from Article 10.1016/j.bmcl.2006.10.057: "SAR studies of 3-arylpropionic acids as potent and selective agonists of sphingosine-1-phosphate receptor-1 (S1P1) with enhanced pharmacokinetic properties."
Assay data:8 Active, 8 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 8 Tested
S1P Receptor Binding Assay from Article 10.1021/jm0503244: "Discovery of potent 3,5-diphenyl-1,2,4-oxadiazole sphingosine-1-phosphate-1 (S1P1) receptor agonists with exceptional selectivity against S1P2 and S1P3."
Assay data:20 Active, 6 Activity ≤ 1 nM, 20 Activity ≤ 1 µM, 20 Tested
In Vitro Binding Assay from US Patent US9663511: "Sphingosine 1-phosphate receptor antagonists"
Assay data:18 Active, 17 Activity ≤ 1 µM, 21 Tested
In Vitro Functional Activity (Agonism) on Human S1P5 Receptors from US Patent US10179791: "Spiro-cyclic amine derivatives as S1P modulators"
In Vitro Functional Activity (Agonism) on Human 51P5 Receptors from US Patent US9670220: "Fused heterocyclic derivatives as S1P modulators"
Assay data:21 Active, 21 Activity ≤ 1 µM, 21 Tested
PRESTO-Tango GPCRome screening (S1PR5)
SummaryRelated BioAssays by Target
Inhibition of S1P5 (unknown origin)
Agonist activity at human recombinant S1P5 expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding measured after 45 mins by liquid scintillation counting assay
Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
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