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PTPN2 Biochemical Assay from US Patent US20240207238: "INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE, COMPOSITIONS, AND METHODS OF USE"
Assay data:10 Active, 1 Activity ≤ 1 nM, 10 Activity ≤ 1 µM, 10 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
PhosphoSens Assay from US Patent US20240207238: "INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE, COMPOSITIONS, AND METHODS OF USE"
Assay data:9 Active, 1 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 9 Tested
Biochemical Assay from US Patent US20240180886: "INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE, COMPOSITIONS, AND METHODS OF USE"
Assay data:51 Active, 5 Activity ≤ 1 nM, 51 Activity ≤ 1 µM, 52 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of TCPTP (unknown origin) by DAS-ELISA
Assay data:6 Active, 1 Activity ≤ 1 µM, 7 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of Flag-tagged human TCPTP (1 to 296 residues) expressed in Escherichia coli BL21 using FDP as substrate
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of TC-PTP (unknown origin) using pNPP as substrate incubated for 5 mins by absorbance based analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of TC-PTP (unknown origin)
Assay data:1 Active, 1 Tested
Inhibition of recombinant TC-PTP (unknown origin)
Assay data:5 Tested
SummaryPubMed CitationRelated BioAssays by Target
Assays for Measuring Biological Activity from US Patent US11597739: "Enhancing CD8+ T cells for adoptive T cell therapy by inhibiting PTPN1 (PTP1B) and PTPN2 (TC-PTP)"
Assay data:10 Active, 7 Activity ≤ 1 µM, 10 Tested
Inhibition of recombinant human TCPTP (1 to 314 residues) expressed in baculovirus-insect cells at 100 uM relative to control
Assay data:4 Tested
Inhibition of recombinant human TCPTP (1 to 314 residues) expressed in baculovirus-insect cells
Assay data:1 Active, 6 Tested
Assay data:3 Tested
Selectivity interaction (Enzyme panel (Panlabs screen)) EUB0000252b PTPN2
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of human TCPTP
Assay data:10 Tested
Inhibition of recombinant human TCPTP expressed in Escherichia coli using p-nitrophenyl phosphate as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins by absorbance based assay
Assay data:2 Active, 2 Tested
Inhibition of TCPTP (unknown origin) by SpectraMax 340 microplate reader Analysis
Assay data:4 Active, 6 Tested
Inhibition of human recombinant TCPTP using pNPP as substrate assessed as reduction in p-nitrophenol release incubated for 30 mins by absorbance based analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 11 Tested
Inhibition of TCPTP (unknown origin) at 25 to 30 uM
Assay data:1 Tested
Inhibition of TC-PTP (unknown origin) at 1 mM using pNPP as substrate
Assay data:4 Active, 4 Tested
Inhibition of PTPN2 (unknown origin) by Mobility shift assay
Assay data:11 Active, 11 Activity ≤ 1 nM, 12 Activity ≤ 1 µM, 12 Tested
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